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Table 1 VEGF inhibitor (PTK787) alters various biological themes in cervix of pregnant rat.

From: Delineation of VEGF-regulated genes and functions in the cervix of pregnant rodents by DNA microarray analysis

Gene Category

Ease score

Steroid Biosynthesis

+6.11

Steroid Metabolism

+4.97

Protein Kinase Activity

~+4

Cell Proliferation

-8.11

Cell Motility

-7.66

Circulation

-3.16

Tissue Remodeling

-3.16

Calcium Channel

-2.5

Immune Response

-4.70

Heat Shock Protein Activity

-8.67

Cell Adhesion Molecule Activity

-1.96

  1. The biological processes, cellular components or molecular functions altered when VEGF action is blocked (VEGF inhibitor) during cervical remodeling (GD20), as revealed by DNA microarray analysis. n = 5.