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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: Delineation of VEGF-regulated genes and functions in the cervix of pregnant rodents by DNA microarray analysis

Figure 1

VEGF siRNA-generating pDNA down regulates VEGF mRNA levels in rat heart fibroblasts. The VEGF gene silencing efficiency by the three siRNA-generating pDNAs were tested in vitro using rat heart fibroblast primary cell transfection. VEGF siRNA-generating pDNA was found to down-regulate VEGF in cultured rat heart fibroblasts compared to control. The pDNA with the best silencing efficiency was selected and used in the rat cervix to test its efficiency to down-regulate local cervical VEGF in vivo (see Figure 2). n = 5, (p < 0.05).

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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