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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis

Figure 3

Schematic representation of molecular pathways possibly involved in the pathogenesis of endometriosis. The overexpression of SHC1, ACTN4, and AXL observed in the endometriotic samples may lead to the activation of the PI3K and MAPK signaling pathways in human endometriosis. The purple arrows indicate the genes which were shown to be overexpressed in human endometriosis by the SAGE and IHC of the present study. In addition, the red arrows indicate the genes which are activated or inactivated in the mouse model of endometriosis. PIK3CA encodes p110 alpha catalytic subunit of PI3K.

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