Figure 5
Regression analysis. Linear regression analysis of TIMP activity assay results versus (A) TIMP-1 molar protein concentration (R = 0.71, p < 0.001), (B) the TIMP-1/(MMP-8 + MMP-9) molar ratio (R = 0.65, p = 0.002) and (C) the (TIMP-1 + α2M)/(MMP-8 + MMP-9) molar ratio (R = 0.64, p = 0.002). The MMP-2 (64 kDa) lysis band intensities represent the fraction of 10 pg MMP-2 that the inhibitors in CMP were able to bind in percent of the intensity of the standard containing 10 pg of active MMP-2 alone.