Changes in food intake of rats treated with OE during the second half of pregnancy. The black bar indicates the period of treatment. P1, P11 and P21 refer to days 1, 11 and 21 of pregnancy and L20 refers to day 20 after delivery. Statistical differences: two-way ANOVA; factor time (P < 0.0001), factor treatment (P < 0.0001), significant interaction between factors (P = 0.0003). Bonferroni post-hoc test: There were significant differences between the groups from days 1, 16, 17 and 19 after delivery (* = P < 0.05).