Weight changes of OE-treated rats and their pups during pregnancy. A) Weight changes in dams. The black bar indicates the period of treatment. P1, P11 and P21 refer to days 1, 11 and 21 of pregnancy and L20 refers to day 20 after delivery. Statistical differences: two-way ANOVA; factor time (P < 0.0001), factor treatment (P < 0.0001) and significant interaction (P = 0.0001). Bonferroni post-hoc test: the weights of treated rats showed no differences. B) Weight changes in pups from control or OE-treated mothers during pregnancy. Statistical differences: two-way ANOVA; factor time (P < 0.0001), factor treatment (P < 0.0001), significant interaction between factors (P = 0.0002). Bonferroni post-hoc test: * = P < 0.05. There were significant differences between groups from day 27 onwards.