Progesterone induces surface expression of EMP2 in mouse endometrium in vivo. Mice were injected with progesterone or sesame oil (control) daily for up to 5 days. Tissue was harvested at days 1, 2, and 4 of treatment or 3 days following completion of treatment, processed for immunohistochemistry, and then stained for EMP2 expression (A-D) or a vehicle control (E). (A) 24 hours of progesterone treatment; (B) 48 hours of treatment; (C) 4 days of treatment; (D) 3 days following treatment; (E) representative control treatment at 4 days. Magnification: (left) 100×; (right) 400×. The experiment was repeated at least 3 times with similar results; representative images are shown.