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Table 3 Dosage compensation mechanisms: an overview of their basic characteristics

From: Regulatory RNAs and chromatin modification in dosage compensation: A continuous path from flies to humans?

Feature

Drosophila

Mammals

Gene regulation result

Hypertranscription

Transcriptional silencing

Genes escaping effect

Different cases already established

Established (humans/mice)

Clonality

Assumed

Established

Outcome in case of Quantitative Chromosomal Abnormalities

Sex reversal or lethality (sex determined by the ratio of autosomes to gonosomes)

All but one X are inactivated in diploid cells (X-1 rule)

  1. Comparison of the basic characteristics of dosage compensation in flies and mammals.