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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: Regulatory RNAs and chromatin modification in dosage compensation: A continuous path from flies to humans?

Figure 5

While both roX and Xist retain the ability to initiate dosage compensation when transferred to an autosome, Xist has the potency to spread along the entire chromosome, whereas roX has only been known to affect neighboring genes. However, even in the case of Xist RNA, the ability to spread along an entire chromosome depends on both the number of gene copies and the presence of an adequate number of booster elements (i.e. binding sequences, such as Line 1).

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