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Table 3 Differentially expressed genes in leiomyomas compared to keloids/incesional scars

From: Genomic and proteomic profiling II: Comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically-induced scars

Gene Bank

Symbol

F. Change

LAA:Scar

F. Change

LC:Scar

P value

Function

NM_006198

PCP4

68.14

6.66

0.0017

system development

S67238

MYOSIN

62.78

36.69

0.0034

cytoskeleton/motility

NM_004342

Cald1

21.43

9.32

0.0047

cytoskeleton/motility

NM_013437

LRP12

20.6

6.82

0.0053

cellular process

AC004010

AMIGO2

19.07

10.61

0.0021

cell adhesion

AF040254

OCX

18.71

5.39

0.0099

signal transduction

NM_015385

SORBS1

17.44

9.26

0.0003

cytoskeleton/motility

NM_012278

ITGB1BP2

17.42

9.9

0.0018

signal transduction

NM_006101

KNTC2

17.33

5.23

0.0022

transcription factor

NM_001845

COL4A1

16.08

5.94

0.0029

cytoskeleton/motility

AF104857

CDC42EP3

16.08

3.78

0.0002

cytoskeleton/motility

AW188131

DDX17

15.65

9.11

0.0005

translation factor

NM_001057

TACR2

15.6

4.51

0.0062

signal transduction

AI375002

ZNF447

14.55

8.04

0.0061

transcription factor

NM_014890

DOC1

14.35

5.19

0.0002

proteolysis

NM_001784

CD97

13.16

6.35

0.00004

signal transduction

BF111821

WSB1

12.34

7.36

0.0024

signal transduction

AW152664

PNN

12.19

8.26

0.003

transcription factor

NM_002380

MATN2

11.86

5.62

0.0011

extracellular matrix

NM_007362

NCBP2

11.38

8.04

0.0034

RNA processing

AK023406

Macf1

8.8

4.77

0.0041

ECM signaling

AF095192

BAG2

8.01

4.34

0.0018

apoptosis

NM_004196

CDKL1

7.91

2.83

0.0017

cell cycle

BF512200

MBNL2

7.58

3.01

0.0014

muscle differentiaon

AW043713

Sulfl

6.9

0.78

0.0039

hydrolase activity

NM_004781

VAMP3

6.76

3.02

0.0016

trafficking

AI149535

STAT5B

5.62

3.94

0.0043

transcription factor

NM_016277

RAB23

5.61

2.68

0.0055

signal transduction

AI582238

TRA1

5.13

3.46

0.0042

calcium ion binding

NM_005722

ACTR2

4.04

2.49

0.0001

cytoskeleton/motility

AF016005

RERE

4.02

2.87

0.008

transcription factor

AL046979

TNS1

3.65

2.14

0.0047

signal transduction

NM_005757

MBNL2

3.57

0.84

0.0049

muscle development

AJ133768

LDB3

3.3

1.53

0.0056

cytoskeleton/motility

AI650819

CUL4B

3.04

1.59

0.0045

metabolism

AL031602

MT1K

0.61

0.33

0.0086

cadmium ion binding

U85658

TFAP2C

0.27

0.14

0.0083

transcription factor

NM_003790

TNFRSF25

0.19

0.11

0.007

apoptosis

BC002495

BAIAP2

0.18

0.11

0.0003

signal transduction

AV691491

TMEM30B

0.13

0.09

0.0093

cell cycle control

AI889941

COL4A6

10.4

30.21

0.007

extracellular matrix

AW451711

PBX1

14.44

18.14

0.0001

transcription factor

NM_014668

GREB1

7.18

15.94

0.0089

 

NM_004619

TRAF5

6.47

11.46

0.0091

signal transduction

NM_005418

ST5

5.83

8.1

0.0044

signal transduction

BC002811

SUMO2

0.47

0.83

0.0035

protein binding

AV700891

ETS2

0.28

0.54

0.0082

transcription factor

AB042557

PDE4DIP

0.2

0.39

0.0019

signaling

NM_014485

PGDS

0.17

0.31

0.0027

catalytic activity

AI984221

COL5A3

0.08

0.17

0.0011

extracellular matrix

NM_006823

PKIA

0.08

0.17

0.0034

Kinase regulator

AU144284

IRF6

0.04

0.15

0.0026

transcription factor

NM_000962

PTGS1

0.06

0.11

0.0046

catalytic activity

NM_022898

BCL11B

0.05

0.09

0.0099

transcription factor

NM_001982

ERBB3

0.02

0.06

0.0066

signal transduction

NM_002705

PPL

0.005

0.031

0.0073

hydrolase activity

NM_001630

ANXA8

0.006

0.02

0.0079

calcium ion binding

N74607

AQP3

0.006

0.02

0.0098

transporter activity

NM_000142

FGFR3

0.007

0.009

0.01

Growth factor

Receptor

     
  1. Partial list of differentially expressed genes from several functional categories in leiomyomas from African Americans and Caucasians as compared to keloids/incesional scars as shown in Fig. 2. The genes were selected based on p ranking of p ≤ 0.01 and following 2-fold cutoff change