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Table 1 List of over-expressed in leiomyomas as compared to scar tissues (keloids/incesional scars)

From: Genomic and proteomic profiling II: Comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically-induced scars

Gene Bank

Symbol

Fold Change

Probability

Function

NM_003478

CUL5

5.06

0.0001

apoptosis

AB037736

CASP8AP2

4.07

0.0021

apoptosis

NM_018947

CYCS

2.08

0.0013

apoptosis

AB014517

CUL3

2.07

0.00001

apoptosis

BC010958

CCND2

5.62

0.0041

cell cycle

U47413

CCNG1

3.16

0.0007

cell cycle

AF048731

CCNT2

2.83

0.0004

cell cycle

NM_001927

DBS

61.51

0.0022

cytoskeleton/motility

AK124338

ACTG2

30.16

0.00001

cytoskeleton/motility

BC022015

CNN1

27.26

0.00001

cytoskeleton/motility

NM_006449

CDC42EP3

25.29

0.0051

cytoskeleton/motility

AB023209

KIAA0992

17.61

0.0004

cytoskeleton/motility

AF474156

TPM1

14.84

0.0029

cytoskeleton/motility

BC011776

TPM2

12.04

0.00001

cytoskeleton/motility

M11315

COL4A1

11.87

0.0029

cytoskeleton/motility

AK126474

LMOD1

9.49

0.00001

cytoskeleton/motility

AB062484

CALD1

9.22

0.0042

cytoskeleton/motility

NM_003186

TAGLN

6.68

0.00001

cytoskeleton/motility

BC017554

ACTA2

5.18

0.00001

cytoskeleton/motility

AK074048

FLNA

5.08

0.00001

cytoskeleton/motility

NM_016274

CKIP-1

4.44

0.002

cytoskeleton/motility

BC003576

ACTN1

4.23

0.0024

cytoskeleton/motility

AF089841

FLNC

3.43

0.0005

cytoskeleton/motility

X05610

COL4A2

7.86

0.0017

extracellular matrix

BC005159

COL6A1

3.70

0.002

extracellular matrix

A98730

CAPN6

13.7

0.0023

protease activity

U41766

ADAM9

4.76

0.0021

protease

NM_001110

ADAM10

3.2

0.00001

protease

AF031385

CYR61 (CCN1)

9.13

0.0035

growth factor

M32977

VEGF

7.13

0.002

growth factor

AF035287

SDFR1

4.70

0.0001

chemokine receptor

X04434

IGF1R

3.64

0.0017

growth factor receptor

AB029156

HDGFRP3

2.89

0.0006

GF receptor activity

AF056979

IFNGR1

2.72

0.0001

signal transduction

AB020673

MYH11

53.80

0.0006

signal transduction

D26070

ITPR1

26.18

0.0034

signal transduction

AB037717

SORBS1

15.25

0.0005

signal transduction

AF110225

ITGB1BP2

14.18

0.0009

signal transduction

AB004903

SOCS2

11.39

0.0002

signal transduction

B011147

GREB1

11.37

0.0025

signal transduction

AB000509

TRAF5

7.83

0.0032

signal transduction

NM_005261

GEM

7.48

0.0003

signal transduction

AF028832

HSPCA

4.27

0.00001

signal transduction

AC006581

M6PR

3.85

0.0012

signal transduction

AF275719

HSPCB

3.74

0.001

signal transduction

AJ242780

ITPKB

3.68

0.00001

signal transduction

AK095866

GPR125

3.62

0.0001

signal transduction

AF016050

NRP1

3.44

0.0011

signal transduction

AB015706

IL6ST

3.42

0.0002

signal transduction

AK057120

HMGB1

3.16

0.0001

signal transduction

NM_006644

HSPH1

3.14

0.002

signal transduction

AB072923

BSG

2.90

0.0024

signal transduction

AB010881

FZD7

2.62

0.0024

signal transduction

AF273055

INPP5A

2.58

0.002

signal transduction

AC078943

TANK

2.32

0.0005

signal transduction

AF051344

LTBP4

2.20

0.0002

signal transduction

AJ404847

ILK

4.74

0.0002

protein kinase activity

AF119911

CSNK1A1

3.40

0.0015

protein kinase activity

NM_002037

FYN

3.30

0.0028

protein kinase activity

AB058694

CDC2L5

2.37

0.0001

protein kinase activity

AF415177

CAMK2G

2.18

0.0008

protein kinase activity

NM_005654

NR2F1

12.57

0.0039

transcription factor

BC062602

PNN

9.93

0.0001

transcription factor

AK098174

MEIS1

9.61

0.00001

transcription factor

NM_000125

ESR1

9.36

0.0004

transcription factor

AF249273

BCLAF1

8.62

0.0001

transcription factor

AF017418

MEIS2

7.46

0.0009

transcription factor

AF045447

MADH4

6.39

0.00001

transcription factor

AF162704

AR

5.54

0.0018

transcription factor

NM_001527

HDAC2

4.76

0.00001

transcription factor

NM_004268

CRSP6

4.76

0.0001

transcription factor

BC020868

STAT5B

4.57

0.0003

transcription factor

BC002646

JUN

3.84

0.0042

transcription factor

AY347527

CREB1

3.77

0.0031

transcription factor

AL833643

MAX

3.66

0.0014

transcription factor

NM_021809

TGIF2

3.58

0.0014

transcription factor

AB007836

TGFB1I1

3.55

0.0007

transcription coactivator

NM_005760

CEBPZ

3.53

0.00001

transcription factor

AL833268

MEF2C

3.49

0.0019

transcription factor

NM_005903

MADH5

3.10

0.0037

transcription factor

NM_022739

SMURF2

2.58

0.0013

transcription factor

NM_003472

DEK

2.55

0.0001

transcription factor

NM_001358

DHX15

2.49

0.0029

transcription factor

BC029619

ATF1

2.41

0.0026

transcription factor

AB082525

TSC22

2.26

0.0002

transcription factor

AL831995

MEF2A

2.25

0.0024

transcription factor

AA765457

DDX17

10.41

0.0035

translation factor

NM_018951

HOXA10

8.69

0.00001

translation factor

BC000751

EIF5A

4.07

0.001

translation factor

AF015812

DDX5

2.48

0.0004

translation factor

AL079283

EIF1A

2.35

0.0005

translation factor

NM_003760

EIF4G3

2.35

0.0028

translation factor

NM_012218

ILF3

2.29

0.0003

translation factor

AB018284

EIF5B

2.26

0.002

translation factor

AF155908

HSPB7

9.52

0.0002

protein binding

AF209712

MCP

6.54

0.00001

complement activation

AL833430

SPARCL1

5.12

0.00001

calcium ion binding

AF297048

PTGIS

4.26

0.0004

catalytic activity

AF288537

FSTL1

4.11

0.001

calcium ion binding

AB034951

HSPA8

3.13

0.001

protein binding

NM_001155

ANXA6

2.85

0.0014

calcium ion binding

NM_003642

HAT1

2.81

0.00001

catalytic activity

NM_002267

KPNA3

2.55

0.0031

protein transporter

AK124769

XPO1

2.46

0.0002

protein transporter

AJ238248

CENTB2

2.37

0.0045

GTPase activator activity

AF072928

MTMR6

2.17

0.002

phosphatase activity

  1. Partial list of differentially expressed genes identified in leiomyomas (African Americans and Caucasians) as compared to keloid/incisional scars as shown in Fig. 1. The genes were selected based on p ranking of p ≤ 0.005 and 2-fold cutoff change selection (F. Change) as described in materials and methods. Table 1 displays the over-expressed genes in leiomyomas as compared to keloid/incisional scars.