Genomic and proteomic profiling I: Leiomyomas in African Americans and Caucasians

Pan, Qun; Luo, Xiaoping; Chegini, Nasser

doi:10.1186/1477-7827-5-34

Reproductive Biology and Endocrinology

Table 1 Differentially expressed genes in leiomyomas of African Americans as compared to Caucasians

From: Genomic and proteomic profiling I: Leiomyomas in African Americans and Caucasians

Gene Bank	Gene Symbol	Probability	Fold Change	Biological Function
P43115	PTGER3	0.007	3.05	signal transduction
NM_006549	CAMKK2	0.0004	2.66	signal transduction
Q92844	TANK	0.00002	2.57	signal transduction
NM_000267	NF1	0.0004	2.57	signal transduction
L35253	MAPK14	0.0011	2.51	signal transduction
Q16825	PTPN21	0.004	2.51	signal transduction
P04156	PRNP	0.00003	2.33	signal transduction
P27986	PIK3R1	0.004	2.19	signal transduction
NM_002835	PTPN12	0.0001	2.18	signal transduction
P04901	GNB1	0.0002	2.02	signal transduction
NM_005456	MAPK8IP1	0.006	0.50	signal transduction
P17612	PRKACA	0.003	0.50	signal transduction
NM_003331	TYK2	0.001	0.50	signal transduction
P17010	ZFX	0.0004	3.73	transcription factor
O00712	NFIB	0.00002	2.56	transcription factor
NM_002040	GABPA	0.004	2.38	transcription
U18671	STAT2	0.001	2.20	transcription
AF040963	MXD4	0.0002	0.50	transcription
Q9Y6K9	IKBKG	0.004	0.50	transcription
L41066	NFATc4	0.001	0.48	transcription
P26196	DDX6	0.008	0.48	RNA processing
O95997	PTTG1	0.009	0.37	oncogenes/tumor suppressors
NM_012141	DDX26	0.0009	0.31	tumor suppressor
P10159	EIF5A	0.0004	2.63	translation
NM_001969	EIF5	0.0001	2.15	translation
NM_000141	FGFR2	0.002	12.66	growth factor receptor
NM_005761	PLXNC1	0.002	3.48	cell receptor
P36897	TGFBR1	0.006	4.81	growth factor receptor
D50683	TGFBR2	0.006	3.54	growth factor receptor
O60462	NRP2	0.002	2.43	cell receptors
O94816	FZD7	0.004	2.04	cell receptors
M26062	IL2RB	0.002	0.46	cell receptors
NM_004883	NRG2	0.007	0.46	cell signaling
M59040	CD44	0.002	2.70	cell surface antigens
P07585	DCN	0.007	2.00	cell surface antigens
P30408	TM4SF1	0.004	2.00	cell surface antigens
M_002456	MUC1	0.008	0.48	cell surface antigens
Q9NVA2	FLJ10849	0.002	3.55	cell cycle
P54826	GAS1	0.001	2.12	cell cycle
Q14004	CDC2L5	0.0001	2.05	cell cycle
NM_003644	GAS7	0.005	0.50	cell cycle
P29466	CASP1	0.008	2.28	apoptosis
NM_016315	GULP1	0.0007	2.04	apoptosis
NM_006595	API5	0.0004	2.02	apoptosis
Q01082 S	PTBN1	0.00005	4.52	cytoskeleton/motility
NM_005909	MAP1B	0.002	3.01	cytoskeleton/motility
P35749	MYH11	0.0005	2.88	cytoskeleton/motility
Q13642	FHL1	0.002	2.59	cytoskeleton/motility
Q9NYL9	TMOD3	0.0002	2.39	cytoskeleton/motility
P35222	CTNNB1	0.005	2.04	cell adhesion receptors
NM_006158	NEFL	0.0006	0.10	cytoskeleton/motility
NM_004995	MMP14	0.003	3.96	protein turnover
NM_013381	TRHDE	0.008	2.33	protein turnover
	LTBP1	0.003	0.50	protein kinase activity
NM_000849	GSTM3	0.0002	7.99	metabolism
NM_000850	GSTM4	0.005	2.36	metabolism
P06733	ENO1	0.005	2.07	metabolism
P08294	SOD3	0.0005	0.44	metabolism
NM_004177	STX3A	0.0007	0.53	trafficking/targeting proteins
Q9NZ08	ARTS-1	0.008	2.20	stress response proteins
AF112465	OGN	0.003	3.05	membrane channels
NM_000725	CACNB3	0.001	0.54	membrane channels
L22548	COL18A1	0.002	0.51	membrane channels
	PTGIS	0.009	2.58	lipid biosynthesis

Partial list of genes from several functional categories differentially expressed in leiomyomas of African Americans as compared to Caucasians as illustrated in figure 1 and selected based on p ≤ 0.001 and 2-fold cutoff change (F. Change) as described in materials and methods. The complete list is provided as in Additional file 1.

Back to article page

ISSN: 1477-7827

Contact us

General enquiries: journalsubmissions@springernature.com