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Figure 4 | Reproductive Biology and Endocrinology

Figure 4

From: THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation

Figure 4

PGF has no effect on BKCa channel activity. A Representative recordings from the same membrane patch (+40mV) in the cell-attached configuration after addition of 20 μM NS1619 and subsequent addition of 1 μM PGF. PGF did not reverse NS1619-stimulated channel activity. B Each bar represents the average channel open probability obtained from cell attached patches (n = 4; +40 mV) before and 15 min after each addition (n = 4). *Significant increase in channel activity compared to control. C & D THG113.31 activates the BKCa channel independently of the FP receptor. Representative recordings from the same membrane patch (+40mV) in the cell-attached configuration before and after addition of 1 μM PGF and subsequent addition of 10 μM THG113.31. Each bar represents the average channel open probability obtained from cell attached patches (n = 3; +40 mV) before and 15 min after each addition (n = 3). *Significant increase in channel activity compared to control.

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