|
Species
|
Mouse
|
Rabbit
|
|---|
|
Strain
|
C57BL/6
|
FVB/N
|
Russen-kaninchen
|
|---|
|
Dose (mg/kg/day)
|
15
|
15
|
50
|
|
Serum level (μM)
|
0.49 ± 0.26
|
0.61 ± 0.17
|
8.39 ± 5.38
|
|
Fertility (fertile/total)
|
0/6
|
6/6
|
5/5
|
- Miglustat was administered to both strains of mice via a miniosmotic pump and miglustat was given to rabbits via their food. Male mice were caged with 2 single females subsequently at week 5 and 6. Male rabbits were mated to one female each. Serum levels were determined from blood serum by means of LC/MS. Data are expressed as means ± SD.
