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Table 2 Serum levels of miglustat in selected strains/species.

From: The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

Species

Mouse

Rabbit

Strain

C57BL/6

FVB/N

Russen-kaninchen

Dose (mg/kg/day)

15

15

50

Serum level (μM)

0.49 ± 0.26

0.61 ± 0.17

8.39 ± 5.38

Fertility (fertile/total)

0/6

6/6

5/5

  1. Miglustat was administered to both strains of mice via a miniosmotic pump and miglustat was given to rabbits via their food. Male mice were caged with 2 single females subsequently at week 5 and 6. Male rabbits were mated to one female each. Serum levels were determined from blood serum by means of LC/MS. Data are expressed as means ± SD.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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