Box and whisker plots are shown depicting the semi-quantitative immunohistochemical staining (HSCORE ± SD) for ER-alpha in normal women throughout the menstrual cycle in proliferative, early, mid and late secretory glandular (A) and luminal (B) epithelium and in stroma (C). In a separate analysis, glandular and luminal ER-alpha HSCOREs were compared between normal fertile mid-secretory endometrium and similar samples in women with endometriosis and suspected defects in uterine receptivity (D). Significance was based on ANOVA with Bonferroni correction; * = p < 0.01, ** = p < 0.001. Abbreviations in the figure: Prolif = proliferative phase, ES = early secretory, MS = mid-secretory, LS = last secretory, gl = glandular epithelium, St = stroma, LU = luminal epithelium, Osis = endometrium from women with endometriosis. Note that the horizontal bars in the box and whisker plots designate the 10th, 25th, 50th, 75th, and 90th percentile distribution of the data and standard error bars are not shown in this figure.