Representative endometrial biopsies of subjects treated with asoprisnil for 28 days. The photographs show examples consistent with the diagnosis "non-physiologic secretory effect". a: Weakly secretory glands with vacuoles below nuclei (solid arrow; Subject MN-6; asoprisnil 10 mg QD); b: Thick-walled vessels (open arrow; Subject MN-6; asoprisnil 10 mg); c: Mild to moderate secretory glands at low magnitude. Note area of relatively dense stroma. (subject MN, 25 mg BID); d: Moderate secretory glands with subnuclear vacuoles at higher magnitude (solid arrow; subject MN, 25 mg BID). QD, once a day. BID, twice a day. From  with permission.