Figure 9From: Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)Representative endometrial biopsies of subjects treated with asoprisnil for 28 days. The photographs show examples consistent with the diagnosis "non-physiologic secretory effect". a: Weakly secretory glands with vacuoles below nuclei (solid arrow; Subject MN-6; asoprisnil 10 mg QD); b: Thick-walled vessels (open arrow; Subject MN-6; asoprisnil 10 mg); c: Mild to moderate secretory glands at low magnitude. Note area of relatively dense stroma. (subject MN, 25 mg BID); d: Moderate secretory glands with subnuclear vacuoles at higher magnitude (solid arrow; subject MN, 25 mg BID). QD, once a day. BID, twice a day. From [10] with permission.Back to article page