Cellular Target of HLA-G | Functional Effect | References |
---|---|---|
Natural killer cell | Prevents cytolytic killing | 24–28 |
 | Inhibits migration | 29 |
 | Induces apoptosis | 30 |
 | Induces proliferation, IFNγ production | 31 |
Blood mononuclear cells | Regulates cytokine production | 32 |
Cytotoxic T cell | Suppresses cytolytic killing | 28, 30, 33, 34 |
 | Regulates cytokine production | 35 |
 | Induces apoptosis | 30, 36, 37 |
 | Decreases expression of CD8 | 22 |
Helper T cell | Decreases proliferation | 38 |
 | Induces suppressive phenotype | 39 |
Monocyte/macrophage | Induces TGF-β1 production | 21 |
Dendritic cell | Reduces stimulatory capacity | 40, 41 |
 | Alters maturation | 41–43 |