Table 1 Immunoregulatory effects of HLA-G.

Natural killer cell

Prevents cytolytic killing

24–28

Inhibits migration

29

Induces apoptosis

30

Induces proliferation, IFNγ production

31

Blood mononuclear cells

Regulates cytokine production

32

Cytotoxic T cell

Suppresses cytolytic killing

28, 30, 33, 34

Regulates cytokine production

35

Induces apoptosis

30, 36, 37

Decreases expression of CD8

22

Helper T cell

Decreases proliferation

38

Induces suppressive phenotype

39

Monocyte/macrophage

Induces TGF-β1 production

21

Dendritic cell

Reduces stimulatory capacity

40, 41

Alters maturation

41–43