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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: The proximal promoter region of mTert is sufficient to regulate telomerase activity in ES cells and transgenic animals

Figure 1

Promoter and regulators elements of the transcriptional of human and mouse TERT. CpG island in human and mouse TERT promoter identify using the CpG Island Explorer Program at http://www.bioinfo.hku.hk/cpgieintro.html are indicated in red line (A). Construct 5 k contain 4.5 Kb of the mouse promoter region, construct 1 k contains the proximal region of the promoter where all the transcription activator elements of the promoter reside (4 regions of c-Myc binding and two regions recognized by proteins from the sp1 family) and construct 2 k, includes, in addition to this proximal region, two of the three regions of MZF2 (myeloid zinc finger protein) binding, that reduces the transcriptional activity of the promoter (B).

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