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Table 2 Differentially expressed genes in the lung according to sex at GDs 15.5, 16.5 and 17.5

From: Sexually dimorphic gene expression that overlaps maturation of type II pneumonocytes in fetal mouse lungs

Id*

Accession number

Gene name†

 

Fold changes‡

   
   

Symbol

GD15.5 (62)§

GD16.5 (33)

GD17.5 (38)

Chr.

Apoptosis

#1

BI662863

Rho-associated coiled-coil forming kinase 1

Rock1

 

2.25

  

#2

NM_011997

caspase 8 associated protein 2

Casp8ap2

 

2.15

 

4 11.4 cM

Cell adhesion

#3

NM_009925

procollagen, type X, alpha 1

Col10a1

M

  

10 22.0 cM

#4

L20232

integrin binding sialoprotein

Ibsp

M

  

5 56.0 cM

#5

NM_031163

procollagen, type II, alpha 1

Col2a1

2.96

F

 

15 54.5 cM

#6

NM_007729

procollagen, type XI, alpha 1

Col11a1

2.25

  

3 53.1 cM

#7

AK004383

procollagen, type IX, alpha 1

Col9a1

1.96

  

1 15.0 cM

#8

U08020

procollagen, type I, alpha 1

Col1a1

  

(1.77)

11 56.0 cM

Cell growth

#9

NM_008341

insulin-like growth factor binding protein 1

Igfbp1

M

  

11 1.3 cM

Coagulation

#10

NM_008877

plasminogen

Plg

F

 

F

17 7.3 cM

#11

AK011118

fibrinogen, B beta polypeptide

Fgb

F

 

F

3 48.2 cM

#12

NM_133862

fibrinogen, gamma polypeptide

Fgg

(3.81)

 

F

3 41.3 cM

#13

BC005467

fibrinogen, alpha polypeptide

Fga

(3.10)

 

F

3 44.8 cM

#14

NM_010168

coagulation factor II

F2

  

(2.67)

2 47.5 cM

Endopeptidase activity

#15

BC012874

serine (or cysteine) proteinase inhibitor, clade A, member 1a

Serpina1a

F

 

F

12 51.0 cM

#16

NM_007443

alpha 1 microglobulin/bikunin

Ambp

F

 

F

4 30.6 cM

#17

NM_010582

inter-alpha trypsin inhibitor, heavy chain 2

Itih2

F

 

F

2 1.0 cM

#18

NM_008407

inter-alpha trypsin inhibitor, heavy chain 3

Itih3

F

 

F

 

#29

NM_007618

serine (or cysteine) proteinase inhibitor, clade A, member 6

Serpina6

(2.66)

 

F

12 51.0 cM

#20

NM_019429

protease, serine, 16 (thymus)

Prss16

 

(2.65)

 

13 10.0 cM

Erythroid-associated

#21

NM_013848

erythroblast membrane-associated protein

Ermap

F

  

4 57.0 cM

#22

AF069311

Rhesus blood group CE and D

Rhced

F

  

4 65.7 cM

#23

NM_053149

hemogen

Hemgn

(3.29)

F

F

 

#24

NM_010635

Kruppel-like factor 1 (erythroid)

Klf1

(3.01)

   

#25

NM_133245

erythroid associated factor

Eraf

(2.38)

   

#26

NM_010369

glycophorin A

Gypa

(2.27)

  

8 36.0 cM

#27

AJ007909

erythroid differentiation regulator 1

Erdr1

  

(1.75)

 

Hormone metabolism/regulation

#28

NM_008293

hydroxysteroid dehydrogenase-1, delta<5>-3-beta

Hsd3b1

M

  

3 49.1 cM

#29

AV021656

aldo-keto reductase family 1, member B7

Akr1b7

M

  

6 14.0 cM

#30

NM_009995

cytochrome P450, family 21, subfamily a, polypeptide 1

Cyp21a1

M

   

#31

AI195150

group specific component

Gc

F

 

F

5 44.0 cM

#32

BG141874

transthyretin

Ttr

(3.93)

F

F

18 7.0 cM

#33

NM_031192

renin 1 structural

Ren1

3.67

F

  

#34

NM_007423

alpha fetoprotein

Afp

(2.64)

 

F

5 50.0 cM

#35

U63146

retinol binding protein 4, plasma

Rbp4

(1.89)

 

(2.16)

19 38.0 cM

Immune functions

#36

NM_011558

T-cell receptor gamma, variable 4

Tcrg-V4

F

F

F

 

#37

NM_009019

recombination activating gene 1

Rag1

 

F

F

2 56.0 cM

#38

M58149

CD3 antigen, gamma polypeptide

Cd3g

F

F

 

9 26.0 cM

#39

AF119253

histocompatibility 2, class II antigen A, alpha

H2-Aa

 

F

  

#40

AV058500

P lysozyme structural

Lzp-s

3.42

 

1.70

 

#41

X67128

T-cell receptor beta, variable 13

Tcrb-V13

(1.97)

F

F

6 20.5 cM

#42

BC011474

lymphocyte protein tyrosine kinase

Lck

 

(2.87)

 

4 59.0 cM

#43

BC003476

Ia-associated invariant chain

Ii

 

(2.10)

 

18 32.0 cM

Lipid metabolism

#44

NM_013475

apolipoprotein H

Apoh

F

 

F

11 63.0 cM

#45

NM_009692

apolipoprotein A-I

Apoa1

F

 

F

9 27.0 cM

#46

NM_009695

apolipoprotein C-II

Apoc2

(3.20)

 

F

7 4.0 cM

#47

NM_013474

apolipoprotein A-II

Apoa2

(2.27)

 

F

1 92.6 cM

#48

BC002148

fatty acid binding protein 4, adipocyte

Fabp4

2.33

  

3 13.9 cM

#49

BG922397

p47 protein

p47

1.84

   

Protein biosynthesis

#50

NM_012011

eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked

Eif2s3y

M

M

M

 

#51

NM_009079

ribosomal protein L22

Rpl22

1.86

   

#52

AI642440

ribosomal protein S13

Rps13

(1.81)

   

Signal transduction

#53

X67702

secretoglobin, family 1A, member 1 (uteroglobin)

Scgb1a1

M

   

#54

BF537798

receptor (calcitonin) activity modifying protein 2

Ramp2

2.07

2.16

 

11 61.5 cM

#55

NM_016721

IQ motif containing GTPase activating protein 1

Iqgap1

1.96

  

7 39.0 cM

Transcriptionnal regulation

#56

AA210261

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Ddx3y

M

M

M

Y 2.07 cM

#57

AF127244

jumonji, AT rich interactive domain 1D (Rbp2 like)

Jarid1d

M

M

M

Y 2.03 cM

#58

AA617392

Max protein

Max

 

F

 

12 32.0 cM

#59

BB393998

flap structure specific endonuclease 1

Fen1

3.70

(2.96)

  

#60

NM_007496

AT motif binding factor 1

Atbf1

  

(2.16)

8 E1

Transport

#61

BC024643

albumin 1

Alb1

(2.71)

 

(8.68)

5 50.0 cM

#62

AF440692

Transferring

Trf

(2.02)

 

(3.29)

9 56.0 cM

#63

BB448377

solute carrier family 4 (anion exchanger), member 1

Slc4a1

(2.07)

  

11 62.0 cM

#64

NM_026331

mitochondrial solute carrier protein

Mscp

(1.90)

   

Others

#65

BB742957

ubiquitously transcribed tetratricopeptide repeat gene, Y chr.

Uty

M

M

M

Y 2.06 cM

#66

AI256465

alpha-2-HS-glycoprotein

Ahsg

F

 

F

16 15.0 cM

#67

AK003182

myosin, light polypeptide 1

Myl1

 

F

 

1 34.1 cM

#68

BG806300

inactive X specific transcripts

Xist

(3.34)

(13.22)

(2.41)

X 42.0 cM

#69

AV224521

Gelsolin

Gsn

3.27

  

2 24.5 cM

#70

NM_025711

Asporin

Aspn

2.72

   

#71

BC002136

coronin, actin binding protein 1A

Coro1a

  

(2.48)

7 62.5 cM

#72

AK017440

RNA imprinted and accumulated in nucleus

Rian

 

(2.27)

 

12 54.5 cM

#73

AV156640

expressed in non-metastatic cells 1, protein

Nme1

2.23

   

#74

AF291655

Tenomodulin

Tnmd

2.12

   

#75

BB745314

male-specific lethal-2 homolog (Drosophila)

Msl2

 

(2.11)

  

#76

BB490338

calponin 3, acidic

Cnn3

2.04

   

#77

BB475271

LUC7-like 2 (S. cerevisiae)

Luc7l2

 

1.96

  

#78

NM_053123

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Smarca1

 

1.93

  

#79

BM207360

unc-50 homolog (C. elegans)

Unc50

  

1.91

 

#80

AV011848

malate dehydrogenase 1, NAD (soluble)

Mdh1

1.89

  

11 12.0 cM

#81

AA270173

Lamin B1

Lmnb1

 

(1.89)

 

18 29.0 cM

#82

BB192717

protein phosphatase 2 (formerly 2A), reg. subunit A (PR 65), alpha isoform

Ppp2r1a

 

(1.88)

  

#83

BE372352

ARP3 actin-related protein 3 homolog (yeast)

Actr3

1.77

   

Unknowns

#84

AA717264

Transcribed sequences

  

2.51

  

#85

BC021831

CDNA clone MGC:67258 IMAGE:6413648, complete cds

  

(2.14)

(2.36)

 

#86

AK018316

DNA segment, Chr 2, ERATO Doi 145, expressed

D2Ertd145e

 

2.31

 

2 31.0 cM

#87

BE865094

expressed sequence AI448196

AI448196

  

(2.14)

 

#88

BB151477

RIKEN cDNA 2810468K05 gene

2810468K05Rik

 

1.88

  
  1. *- Identification numbers of genes found in this study. †- Genes are presented in only one functional category although some of them could have been placed in more than one category. ‡- Values with no bracket correspond to higher levels for males, while values in brackets correspond to higher levels for females. The letter M (Male) or F (Female) replace the fold change value when the gene was expressed in one sex only. §- The number of genes differentially expressed at each gestational day (GD) is indicated.