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Table 2 Differentially expressed genes in the lung according to sex at GDs 15.5, 16.5 and 17.5

From: Sexually dimorphic gene expression that overlaps maturation of type II pneumonocytes in fetal mouse lungs

Id* Accession number Gene name   Fold changes    
    Symbol GD15.5 (62)§ GD16.5 (33) GD17.5 (38) Chr.
Apoptosis
#1 BI662863 Rho-associated coiled-coil forming kinase 1 Rock1   2.25   
#2 NM_011997 caspase 8 associated protein 2 Casp8ap2   2.15   4 11.4 cM
Cell adhesion
#3 NM_009925 procollagen, type X, alpha 1 Col10a1 M    10 22.0 cM
#4 L20232 integrin binding sialoprotein Ibsp M    5 56.0 cM
#5 NM_031163 procollagen, type II, alpha 1 Col2a1 2.96 F   15 54.5 cM
#6 NM_007729 procollagen, type XI, alpha 1 Col11a1 2.25    3 53.1 cM
#7 AK004383 procollagen, type IX, alpha 1 Col9a1 1.96    1 15.0 cM
#8 U08020 procollagen, type I, alpha 1 Col1a1    (1.77) 11 56.0 cM
Cell growth
#9 NM_008341 insulin-like growth factor binding protein 1 Igfbp1 M    11 1.3 cM
Coagulation
#10 NM_008877 plasminogen Plg F   F 17 7.3 cM
#11 AK011118 fibrinogen, B beta polypeptide Fgb F   F 3 48.2 cM
#12 NM_133862 fibrinogen, gamma polypeptide Fgg (3.81)   F 3 41.3 cM
#13 BC005467 fibrinogen, alpha polypeptide Fga (3.10)   F 3 44.8 cM
#14 NM_010168 coagulation factor II F2    (2.67) 2 47.5 cM
Endopeptidase activity
#15 BC012874 serine (or cysteine) proteinase inhibitor, clade A, member 1a Serpina1a F   F 12 51.0 cM
#16 NM_007443 alpha 1 microglobulin/bikunin Ambp F   F 4 30.6 cM
#17 NM_010582 inter-alpha trypsin inhibitor, heavy chain 2 Itih2 F   F 2 1.0 cM
#18 NM_008407 inter-alpha trypsin inhibitor, heavy chain 3 Itih3 F   F  
#29 NM_007618 serine (or cysteine) proteinase inhibitor, clade A, member 6 Serpina6 (2.66)   F 12 51.0 cM
#20 NM_019429 protease, serine, 16 (thymus) Prss16   (2.65)   13 10.0 cM
Erythroid-associated
#21 NM_013848 erythroblast membrane-associated protein Ermap F    4 57.0 cM
#22 AF069311 Rhesus blood group CE and D Rhced F    4 65.7 cM
#23 NM_053149 hemogen Hemgn (3.29) F F  
#24 NM_010635 Kruppel-like factor 1 (erythroid) Klf1 (3.01)    
#25 NM_133245 erythroid associated factor Eraf (2.38)    
#26 NM_010369 glycophorin A Gypa (2.27)    8 36.0 cM
#27 AJ007909 erythroid differentiation regulator 1 Erdr1    (1.75)  
Hormone metabolism/regulation
#28 NM_008293 hydroxysteroid dehydrogenase-1, delta<5>-3-beta Hsd3b1 M    3 49.1 cM
#29 AV021656 aldo-keto reductase family 1, member B7 Akr1b7 M    6 14.0 cM
#30 NM_009995 cytochrome P450, family 21, subfamily a, polypeptide 1 Cyp21a1 M    
#31 AI195150 group specific component Gc F   F 5 44.0 cM
#32 BG141874 transthyretin Ttr (3.93) F F 18 7.0 cM
#33 NM_031192 renin 1 structural Ren1 3.67 F   
#34 NM_007423 alpha fetoprotein Afp (2.64)   F 5 50.0 cM
#35 U63146 retinol binding protein 4, plasma Rbp4 (1.89)   (2.16) 19 38.0 cM
Immune functions
#36 NM_011558 T-cell receptor gamma, variable 4 Tcrg-V4 F F F  
#37 NM_009019 recombination activating gene 1 Rag1   F F 2 56.0 cM
#38 M58149 CD3 antigen, gamma polypeptide Cd3g F F   9 26.0 cM
#39 AF119253 histocompatibility 2, class II antigen A, alpha H2-Aa   F   
#40 AV058500 P lysozyme structural Lzp-s 3.42   1.70  
#41 X67128 T-cell receptor beta, variable 13 Tcrb-V13 (1.97) F F 6 20.5 cM
#42 BC011474 lymphocyte protein tyrosine kinase Lck   (2.87)   4 59.0 cM
#43 BC003476 Ia-associated invariant chain Ii   (2.10)   18 32.0 cM
Lipid metabolism
#44 NM_013475 apolipoprotein H Apoh F   F 11 63.0 cM
#45 NM_009692 apolipoprotein A-I Apoa1 F   F 9 27.0 cM
#46 NM_009695 apolipoprotein C-II Apoc2 (3.20)   F 7 4.0 cM
#47 NM_013474 apolipoprotein A-II Apoa2 (2.27)   F 1 92.6 cM
#48 BC002148 fatty acid binding protein 4, adipocyte Fabp4 2.33    3 13.9 cM
#49 BG922397 p47 protein p47 1.84    
Protein biosynthesis
#50 NM_012011 eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Eif2s3y M M M  
#51 NM_009079 ribosomal protein L22 Rpl22 1.86    
#52 AI642440 ribosomal protein S13 Rps13 (1.81)    
Signal transduction
#53 X67702 secretoglobin, family 1A, member 1 (uteroglobin) Scgb1a1 M    
#54 BF537798 receptor (calcitonin) activity modifying protein 2 Ramp2 2.07 2.16   11 61.5 cM
#55 NM_016721 IQ motif containing GTPase activating protein 1 Iqgap1 1.96    7 39.0 cM
Transcriptionnal regulation
#56 AA210261 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Ddx3y M M M Y 2.07 cM
#57 AF127244 jumonji, AT rich interactive domain 1D (Rbp2 like) Jarid1d M M M Y 2.03 cM
#58 AA617392 Max protein Max   F   12 32.0 cM
#59 BB393998 flap structure specific endonuclease 1 Fen1 3.70 (2.96)   
#60 NM_007496 AT motif binding factor 1 Atbf1    (2.16) 8 E1
Transport
#61 BC024643 albumin 1 Alb1 (2.71)   (8.68) 5 50.0 cM
#62 AF440692 Transferring Trf (2.02)   (3.29) 9 56.0 cM
#63 BB448377 solute carrier family 4 (anion exchanger), member 1 Slc4a1 (2.07)    11 62.0 cM
#64 NM_026331 mitochondrial solute carrier protein Mscp (1.90)    
Others
#65 BB742957 ubiquitously transcribed tetratricopeptide repeat gene, Y chr. Uty M M M Y 2.06 cM
#66 AI256465 alpha-2-HS-glycoprotein Ahsg F   F 16 15.0 cM
#67 AK003182 myosin, light polypeptide 1 Myl1   F   1 34.1 cM
#68 BG806300 inactive X specific transcripts Xist (3.34) (13.22) (2.41) X 42.0 cM
#69 AV224521 Gelsolin Gsn 3.27    2 24.5 cM
#70 NM_025711 Asporin Aspn 2.72    
#71 BC002136 coronin, actin binding protein 1A Coro1a    (2.48) 7 62.5 cM
#72 AK017440 RNA imprinted and accumulated in nucleus Rian   (2.27)   12 54.5 cM
#73 AV156640 expressed in non-metastatic cells 1, protein Nme1 2.23    
#74 AF291655 Tenomodulin Tnmd 2.12    
#75 BB745314 male-specific lethal-2 homolog (Drosophila) Msl2   (2.11)   
#76 BB490338 calponin 3, acidic Cnn3 2.04    
#77 BB475271 LUC7-like 2 (S. cerevisiae) Luc7l2   1.96   
#78 NM_053123 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Smarca1   1.93   
#79 BM207360 unc-50 homolog (C. elegans) Unc50    1.91  
#80 AV011848 malate dehydrogenase 1, NAD (soluble) Mdh1 1.89    11 12.0 cM
#81 AA270173 Lamin B1 Lmnb1   (1.89)   18 29.0 cM
#82 BB192717 protein phosphatase 2 (formerly 2A), reg. subunit A (PR 65), alpha isoform Ppp2r1a   (1.88)   
#83 BE372352 ARP3 actin-related protein 3 homolog (yeast) Actr3 1.77    
Unknowns
#84 AA717264 Transcribed sequences    2.51   
#85 BC021831 CDNA clone MGC:67258 IMAGE:6413648, complete cds    (2.14) (2.36)  
#86 AK018316 DNA segment, Chr 2, ERATO Doi 145, expressed D2Ertd145e   2.31   2 31.0 cM
#87 BE865094 expressed sequence AI448196 AI448196    (2.14)  
#88 BB151477 RIKEN cDNA 2810468K05 gene 2810468K05Rik   1.88   
  1. *- Identification numbers of genes found in this study. - Genes are presented in only one functional category although some of them could have been placed in more than one category. - Values with no bracket correspond to higher levels for males, while values in brackets correspond to higher levels for females. The letter M (Male) or F (Female) replace the fold change value when the gene was expressed in one sex only. §- The number of genes differentially expressed at each gestational day (GD) is indicated.