|
Ligand
|
Expressed by
|
Type II receptor
|
Type I receptor
|
Smads
|
References
|
|---|
|
GDF-9
|
oocyte
|
BMPRII
|
ALK5
|
Smad2/3
|
[86-88]
|
|
GDF-9B/BMP-15
|
oocyte
|
BMPRII
|
ALK6
|
Smad1/5/8
|
[91]
|
|
BMP-6
|
oocyte, granulosa cell
|
BMPRII/ActRIIA/B
|
ALK2/ALK3/ALK6
|
Smad1/5/8
|
[94-96]
|
|
TGF-β 1, -2, -3
|
granulosa and theca cell
|
TβRII
|
ALK5
|
Smad2/3
|
[132, 133]
|
|
Activin A/B
|
granulosa cell
|
ActRIIB
|
ALK4
|
Smad2/3
|
[134, 135]
|
|
Inhibin α
|
granulosa cell
|
ActRIIA/ActRIIB
|
?
|
?
|
[136]
|
|
BMP-2
|
granulosa cell
|
BMPRII/ActRIIA
|
ALK3/ALK6
|
Smad1/5/8
|
[137, 138]
|
|
BMP-3
|
granulosa cell
|
ActRIIB
|
?
|
?
|
[106]
|
|
AMH/MIS
|
granulosa cell
|
AMHRII
|
ALK2/ALK3/ALK6
|
Smad1/5/8
|
[111, 113-115]
|
|
BMP-3b
|
theca cell
|
?
|
?
|
?
|
[139]
|
|
BMP-4
|
theca cell
|
BMPRII/ActRIIA
|
ALK3/ALK6
|
Smad1/5/8
|
[137, 138, 140]
|
|
BMP-7
|
theca cell
|
BMPRII/ActRIIA
|
ALK2/ALK3/ALK6
|
Smad1/5/8
|
[140, 141]
|
