Ligand | Expressed by | Type II receptor | Type I receptor | Smads | References |
---|---|---|---|---|---|
GDF-9 | oocyte | BMPRII | ALK5 | Smad2/3 | [86-88] |
GDF-9B/BMP-15 | oocyte | BMPRII | ALK6 | Smad1/5/8 | [91] |
BMP-6 | oocyte, granulosa cell | BMPRII/ActRIIA/B | ALK2/ALK3/ALK6 | Smad1/5/8 | [94-96] |
TGF-β 1, -2, -3 | granulosa and theca cell | TβRII | ALK5 | Smad2/3 | [132, 133] |
Activin A/B | granulosa cell | ActRIIB | ALK4 | Smad2/3 | [134, 135] |
Inhibin α | granulosa cell | ActRIIA/ActRIIB | ? | ? | [136] |
BMP-2 | granulosa cell | BMPRII/ActRIIA | ALK3/ALK6 | Smad1/5/8 | [137, 138] |
BMP-3 | granulosa cell | ActRIIB | ? | ? | [106] |
AMH/MIS | granulosa cell | AMHRII | ALK2/ALK3/ALK6 | Smad1/5/8 | [111, 113-115] |
BMP-3b | theca cell | ? | ? | ? | [139] |
BMP-4 | theca cell | BMPRII/ActRIIA | ALK3/ALK6 | Smad1/5/8 | [137, 138, 140] |
BMP-7 | theca cell | BMPRII/ActRIIA | ALK2/ALK3/ALK6 | Smad1/5/8 | [140, 141] |