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Table 1 Signalling pathways of TGF-β superfamily ligands expressed in the ovary.

From: Smad signalling in the ovary

Ligand Expressed by Type II receptor Type I receptor Smads References
GDF-9 oocyte BMPRII ALK5 Smad2/3 [86-88]
GDF-9B/BMP-15 oocyte BMPRII ALK6 Smad1/5/8 [91]
BMP-6 oocyte, granulosa cell BMPRII/ActRIIA/B ALK2/ALK3/ALK6 Smad1/5/8 [94-96]
TGF-β 1, -2, -3 granulosa and theca cell TβRII ALK5 Smad2/3 [132, 133]
Activin A/B granulosa cell ActRIIB ALK4 Smad2/3 [134, 135]
Inhibin α granulosa cell ActRIIA/ActRIIB ? ? [136]
BMP-2 granulosa cell BMPRII/ActRIIA ALK3/ALK6 Smad1/5/8 [137, 138]
BMP-3 granulosa cell ActRIIB ? ? [106]
AMH/MIS granulosa cell AMHRII ALK2/ALK3/ALK6 Smad1/5/8 [111, 113-115]
BMP-3b theca cell ? ? ? [139]
BMP-4 theca cell BMPRII/ActRIIA ALK3/ALK6 Smad1/5/8 [137, 138, 140]
BMP-7 theca cell BMPRII/ActRIIA ALK2/ALK3/ALK6 Smad1/5/8 [140, 141]