Serum concentrations of estradiol, progesterone, LH and FSH after treatment with vehicle (arrow, open circles) or 0.25 mg/kg VEGF Trap (arrow, closed circles) in the mid-follicular phase in the macaque. Note the timely rise in estradiol, followed by the preovulatory LH/FSH surge and sustained rise in progesterone in controls. VEGF Trap treatment results in a suppression in estradiol and an elevation in LH and FSH but absence of the progesterone rise in the treatment cycle. The progesterone rise indicating ovulation post-treatment took place at 24 days, suggesting recruitment of new follicles was required. Adapted from .