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Table 3 Genes with the highest connectivity scores among all (381) genes up-regulated in the testes of ABP-TG mice.

From: Microarray analysis of androgen-regulated gene expression in testis: the use of the androgen-binding protein (ABP)-transgenic mouse as a model

Name

GenBank ID

Connectivity score

Fold increase

Description

IL-6

X54542

969

2.52

Cytokine; extracellular

AGT

AF045887

927

2.64

Protease inhibitor; extracellular

MYC

L00039

594

2.25

Oncogene, transcription factor; cell cyle, apoptosis

CAT

M29394

405

2.19

Peroxidase; intracellular

EGR1

AV369921

323

2.46

Transcription factor; differentiation, mitogenesis

NTF3

X53257

144

2.41

Growth factor; extracellular

A2M

AI850558

132

2.14

Protease in hibitor; extracellular

LYZS

M21050

132

2.14

Lysozyme; extrecellular

CFTR

AV374675

123

3.40

Ion channel (cystic fibrosis transmembrane conductance regulator); plasma membrane

SHBG

U85644

122

2.41

Androgen-binding protein/ sex hormone binding globulin; extracellular

PGR

M68915

123

2.19

Progesterone receptor; transcription factor

HAND2

U43715

109

2.19

Heart and neural crest derivatives expressed transcript 2; transcription factor

VDR

AW061016

102

2.41

Vitamin D receptor; transcription factor

GDNF

AV296394

99

2.52

Growth factor; extracellular

RAD51

AV311591

97

7.64

DNA repair; meiosis

BTK

AV227438

91

2.14

Tyrosine kinase; intracellular

MAP2K3

X93150

86

2.41

Signal transduction; intracellular

MME

M81591

85

2.00

Metallo-endopeptidase; plasma membrane

CD36

L23108

80

2.05

Collagen type I receptor; cell adhesion, apoptosis; plasma membrane

HSPA8

AV257761

78

2.19

Heat shock protein; chaperone; intracellular