Skip to main content

Table 1 EC 50 and relative binding affinity (RBA) of various steroids and xenobiotics for Arctic char ovarian membrane fractions.

From: Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor

Competitor Concentration (nM) causing 50% displacement RBA (%)
17,20β-P 1.25 100.0
E2 37.9 4.68
P4 52.6 3.37
17α-OH-P 69.3 2.56
11-DOC 132.3 1.34
20β-S 145.2 1.22
DC 207.1 0.86
Flutamide 256.1 0.49
o,p'-DDT 377.5 0.37
o,p'-DDD 549.2 0.30
ZK 112992 1179 0.11
ZK 98299 12879.8 0.01
F 14421.2 0.01
T 18347.21 0.01
11-KT ND 0.0
P5 ND 0.0
Kepone ND 0.0
Nonylphenol ND 0.0
o,p'-DDE ND 0.0
Cimetidine ND 0.0
ORG 31710 ND 0.0
  1. ND indicates substances that did not display 50% displacement of 17,20β-P from its receptor in the range of concentrations examined (steroids: 0.1 nM – 10μM, RBA < 0.01%; xenobiotics, hormone antagonists: 0.1 nM – 1 mM, RBA < 0.0001%).