Zebrafish sex determination and differentiation: Involvement of FTZ-F1 genes

Table 1 Chromosomal location and dose effects. Several genes involved in mammalian sex determination have dose effects leading to sex reversal.

Chromosomal location	Gene	Number of copies	Phenotype	Reference
Y Chromosome	SRY	0	Female
		1	Male	[12]
X Chromosome	Dax-1	1	Normal
		2	Female XY	[13]
Autosomal	Sox9	1	Female XY	[14,15]
Masculinizing		2	Normal
		3	Male XX	[16]
Autosomal	SF-1	1	Female XY	[17]
Masculinizing		2	Normal
Autosomal	WT1	1	Female XY	[18]
Masculinizing		2	Normal
Autosomal	Dmrt1	1	Female XY	[19]
Masculinizing		2	Normal

ISSN: 1477-7827