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Table 6 Advantages of the third generation aromatase inhibitors:

From: The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

• Extremely potent in inhibiting the aromatase enzyme

• Very specific in inhibiting the aromatase enzyme without significant inhibition of the other steroidogenesis enzymes

• Orally administered

• 100% bioavailability after oral administration

• Rapid clearance from the body (Short half-life, ~45 hours)

• No accumulation of the medications or their metabolites

• No significant active metabolites

• Well tolerated on daily administration for years

• Few side effects

• Very safe without significant contraindications

• Relatively inexpensive