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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Estrogen regulation of testicular function

Figure 3

ER agonists regulate androgen biosynthesis in Leydig cells. Incubation of mature rat Leydig cells, from 90-day old rats, with estrogenic chemicals, i.e., bisphenol A (BPA)(A), the synthetic estrogen diethylstilbestrol DES (B) and a biologically active metabolite of the pesticide methoxychlor (HPTE)(C), caused an inhibitory effect on androgen biosynthesis albeit at different doses. Using RT-PCR, ERβ was not detected in these cells, implying that inhibitory effects were ERα-mediated (ref. 89). Copyright 2004, The Endocrine Society.

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