Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing

Table 1 The day of vaginal opening and regular estrous cycle of the rats

	N (n = 18)	V (n = 18)	M (n = 18)	HM (n = 18)	S (n = 18)
Day of vaginal opening	34.00 ± 0.98	34.33 ± 1.09	25.97 ± 2.24*	32.56 ± 1.04^#	24.78 ± 1.01*
Day of regular estrous cycle	41.26 ± 2.35	45.00 ± 1.19	32.43 ± 0.75*	40.58 ± 0.84^#	34.56 ± 0.89*
Blood estrogen (pg/ml)	22.64 ± 3.69	24.58 ± 3.87	50.36 ± 5.54*	30.98 ± 7.02^#	51.14 ± 4.98*

*p < 0.05 vs N and V, respectively; # p < 0.05 vs M and S, respectively
N: intact normal, M: IPP model, V: vehicle with no IPP, HM: IPP model exposed to herb mixture, S: IPP model exposed to saline

ISSN: 1477-7827