PGF2alpha induced differential expression of genes involved in turnover of extracellular matrix in rat decidual cells

Table 1 Effect of PGF_2α on the expression of genes related to the extracellular matrix (ECM).

Gene Bank number	Swiss protein number	Name	Function	Ratio	% decrease	Fold increase
U65656	P97581	Gelatinase A	Metalloproteinase	0.04 ± 0.02	87.53
Y00697	P07154	Cathepsin L	Cysteine protease	0.09 ± 0.05	91.09
L31884	P30121	Tissue inhibitor metalloproteinase 2 (TIMP2)	Protease inhibitor	0.05 ± 0.01	95.54
U27201	P48032	Tissue inhibitor metalloproteinase 3 (TIMP3)	Protease inhibitor	0.04 ± 0.01	91.95
X63434	P29598	Urokinase type Plasminogen activator (uPA)	Serine protease	0.14 ± 0.09	94.86
M24067	P20961	Plasminogen activator inhibitor (PAI)	Protease inhibitor	0.09 ± 0.05	91.68
M2367	P19367	Tissue type plasminogen activator (tPA)	Serine protease	0.17 ± 0.02	89.90
X71071	Q08290	Calponin	Cytoskeleton	0.08 ± 0.004	92.50
U06755	P37397	Calponin, acidic	Cytoskeleton	0.24 ± 0.13	76.76
U62897	O35850	Carboxypeptidase D	Carboxypeptidase	0.24 ± 0.14	76.48
M64711	P22388	Endothelin 1	Hormone	0.34 ± 0.2	77.48
X02601	P03957	Polypeptide, 53 kDa, growth factor induced	Metalloproteinase	2.54 ± 1.04		3
J03552	P14046	Plasma proteinase inhibitor α1-inhibitor III	Protease inhibitor	3.64 ± 0.64		4
M32247	P17475	α1 antiproteinase	Protease inhibitor	2.45 ± 0.44		3

Ratio = net intensity of PGF_2α normalized/net intensity of control normalized, and represent the mean ± SEM of each ratio from separate experiments. Ratio > 2 = up regulation; ratio < 0.5 = down regulation; 0.5 < Ratio < 2 = equal expression.

ISSN: 1477-7827