Figure 2

Gene expression in IL11Ra^+/+ and IL11Ra^-/- uterus following artificial decidualization. Expression profiling of 15K genes between IL11Ra^+/+ and IL11Ra^-/- at 0 h (A, B), 18 h (C, D), 24 h (E, F) and 48 h (G, H) following the artificial induction of decidualization. Each volcano style plot shows the normalized log ratio (effect estimate) of IL11Ra^-/- compared to wild type for each gene from a series of 4 microarrays, plotted against the log odds of differential expression. A, C, E, G represent the first replicates, and B, D, F, H the second dye-swapped replicates. Genes with log odds of differential expression greater than 3 (ie. adjusted p-value < 0.05, above horizontal line) are represented by open circles, and COL3A1, BGN, SPARC and NID1 are labeled in G and H. Only those genes with log odds of differential expression greater than 3 in both replicates were considered differentially expressed, as described in Methods.