Figure 1From: Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implicationsOverview of the human folate- and vitamin B12-dependent homocysteine metabolism indicating its one-carbon donors and acceptors involved in methyl group biogenesis and DNA synthesis. MTHFR, methylenetetrahydrofolate reductase; MSR, methionine synthase reductase; dUMP, deoxyuridylate; dTMP, deoxythymidylate.Back to article page