Table 4 Nonclassical targets for members of the PRL family
Biological Targets | Ligands (function) | References |
|---|---|---|
Endothelial cells | PLF (angiogenic) PLF-RP (anti-angiogenic) 16kDa-PRL (anti-angiogenic) | 104, 112–115 |
Hematopoietic precursors | PLP-E and PLP-F (promote erythrocyte and megakaryocyte development) | 105–107 |
Natural killer cells | PLP-A (modulator of the uterine natural killer cell phenotype) | 108, 109 |
Eosinophils | Decidual PRP (unknown) | 71 |
Hepatocytes | PLP-C, PLP-N (unknown) | S. Ohboshi, J. Bustamante, M.J. Soares, unpublished results |