From: Transgenic nonhuman primates for neurodegenerative diseases
Disease | Mutant Gene | Mutation | Transgenic Mouse Model |
---|---|---|---|
FAD | APP | Mainly missense | Mutant APP and APP:PS1 |
FAD | PS1 | Mainly missense | Mutant PS1 |
FAD | PS2 | Mainly missense | Mutant PS2 |
FALS | SOD1 | Mainly missense | Mutant SOD1 |
FTDP-17 | Tau | Missense & splice | Mutant Tau |
PD | α-synuclein | Missense | wt/mutant αsyn |
Prion | PrP | Mainly missense | Mutant PrP |
HD | huntingtin | Polyglutamine | huntingtin (expanded repeat) |
SCA-1 | ataxin-1 | Polyglutamine | ataxin-1 (expanded repeat) |
SCA-3 | ataxin-3 | Polyglutamine | ataxin-3 (expanded repeat) |
DRPLA | atrophin-1 | Polyglutamine | atrophin-1 (expanded repeat) |