From: Biology of primate relaxin: A paracrine signal in early pregnancy?
Cell Type | Kd (nM)/# binding sites per cell * | Intracellular signal or Biological Effect | Reference |
---|---|---|---|
Human THP-1 Monocytes | 0.102/275 | ↑ cAMP ↑ Extracellular acidification | [195] |
Human Uterine Fibroblast | 4.4 ± 1.7/3220 ± 557 | ↑ Tyrosine phosphorylation | [196] |
Human Uterine Epithelial Cells | 0.44/1082 ± 62 | NA | [28] |
Human Endometrial Stromal Cells | 0.150/963–1000 | ↑ p42/44 MAPK activity ↑ Activation of CREB ↑ VEGF expression ↑ cAMP ↑ Prolactin gene expression | [103] [119] [197] |
Human Sperm | 0.650/NA | ↑ Sperm motility ↑ Acrosome reaction | [198] |
Human Granulosa Cells | NA | ↑ Release of calcium from intracellular stores | [199] |