Skip to main content

Table 2 Binding characteristics of recombinant human relaxin at putative binding sites and intracellular signals affected.

From: Biology of primate relaxin: A paracrine signal in early pregnancy?

Cell Type Kd (nM)/# binding sites per cell * Intracellular signal or Biological Effect Reference
Human THP-1 Monocytes 0.102/275 ↑ cAMP
↑ Extracellular acidification
[195]
Human Uterine Fibroblast 4.4 ± 1.7/3220 ± 557 ↑ Tyrosine phosphorylation [196]
Human Uterine Epithelial Cells 0.44/1082 ± 62 NA [28]
Human Endometrial Stromal Cells 0.150/963–1000 ↑ p42/44 MAPK activity
↑ Activation of CREB
↑ VEGF expression
↑ cAMP
↑ Prolactin gene expression
[103]
[119]
[197]
Human Sperm 0.650/NA ↑ Sperm motility
↑ Acrosome reaction
[198]
Human Granulosa Cells NA ↑ Release of calcium from intracellular stores [199]
  1. cAMP = cyclic adenosine monophosphate; CREB = cAMP response element binding protein; MAPK, mitogen-activated protein kinase; NA = data not available; VEGF = vascular endothelial growth factor. The asterisk (*) indicates that reported estimates for Kd values may be different due to tissue and radioligand differences, or both.