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Table 3 Challenges in manipulation of the placental phenotype

From: Pregnancy initiation in the rhesus macaque: Towards functional manipulation of the maternal-fetal interface

• Targeted delivery of vector to the placenta: promoter and receptor-based approaches
• Implementation of gene knock-down technology
• Regulated expression would be of significant utility
• Useful approaches will include minimally invasive monitoring of transgene expression during pregnancy
• Improvement in vector application (replacement vs. insertion)
• Alignment of enthusiasm with reality of resource availability = prioritization of research goals