Figure 4

Formation of the deciduoma extends pseudopregnancy by stimulating prolactin and progesterone production Deciduoma-bearing pseudopregnant rats were injected with the dopaminergic agonist CB154 (2 mg/kg s.c.) at 10:00 h on day 10 of PSP, and sacrificed at 18:00 h on the following day. The group receiving CB154 was compared with a control sham-operated pseudopregnant group and a deciduoma-bearing pseudopregnant group, which were treated with vehicle alone. Trunk blood was obtained after decapitation in all animals and serum PRL (Panel B) and progesterone (Panel C) concentrations were measured by RIA. In three similarly treated groups of animals, extension of PSP was measured (Panel A). Results are mean ± SEM of groups of 6–9 animals. Columns with different letters are statistically different. a vs. b, p < 0.01.