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Figure 7 | Reproductive Biology and Endocrinology

Figure 7

From: Origin of germ cells and formation of new primary follicles in adult human ovaries

Figure 7

Serial sections through the intravascular oocyte-nest assembly. Serial sections (7 μm thick) through the oocyte-nest assembly show bottom of the complex (A); oocyte nucleus (n) plane (B); intermediate section (is) and the tail (t) plane (C); and top of the complex (D). v, vascular wall; vp, vascular pocket; blue arrowheads, ZP+ extensions from the oocyte intermediate section – anchors to the vascular wall; yellow arrowheads, nest extensions penetrating the ooplasm; blue arrows, ZP+ staining (oocyte signaling). Insets in panel B show putative germ cell with ZP+ intermediate section (arrowhead) migrating in the upper ovarian cortex. Insets in panel D show an association of putative germ cell with a cortical vessel (v) wall – note ZP+ intermediate section containing a CK+ "eye" (arrowhead). Details in text. Immunostaining with CK18 (brown color) and HSPZ (blue color). No hematoxylin counterstain.

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