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Table 6 Cross-sectional analysis: percent change (95% CIs) in sex hormone concentrations in relation to interquartile range increase in urinary phthalate metabolite concentration by visit during gestation

From: Urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels during pregnancy: a longitudinal analysis

Visit 1 (16–20 weeks)
Analyte % Change (95% CI) p-value % Change (95% CI) p-value % Change (95% CI) p-value
  Estradiol (n = 97 observations) SHBG (n = 83 observations) ln-progesterone (n = 98 observations)
MBzP -5.65 (-18.9, 7.57) 0.40 4.99 (-4.43, 14.4) 0.29 1.88 (-6.60, 11.3) 0.66
MBP 0.20 (-10.3, 14.2) 0.75 4.13 (-3.66, 11.9) 0.29 5.68 (-2.41, 13.7) 0.18
MiBP -0.99 (-13.1, 11.1) 0.87 -0.92 (-9.77, 7.28) 0.77 5.56 (-2.46, 13.9) 0.18
MEP 0.03 (-15.5, 15.6) 1.00 -10.1 (-21.8, 1.65) 0.09† -12.15 (-20.5, -2.99) 0.01*
MCPP -2.93 (-14.4, 8.54) 0.61 -2.66 (-10.6, 5.27) 0.51 -0.42 (-7.61, 7.34) 0.91
MCOP 0.70 (-9.86, 11.3) 0.90 0.86 (-6.74, 8.48) 0.82 -0.57 (-7.27, 6.62) 0.87
MCNP 2.43 (-7.42, 12.3) 0.63 -0.65 (-7.75, 6.45) 0.86 -0.58 (-6.85, 6.11) 0.86
ΣDEHP -7.50 (-20.9, 5.92) 0.27 -5.93 (-15.4, 3.54) 0.22 2.37 (-6.23, 11.9) 0.59
Visit 3 (24–28 weeks)
  Estradiol (n = 78 observations) SHBG (n = 64 observations) ln-progesterone (n = 81 observations)
MBzP 4.38 (-7.12, 15.9) 0.45 6.66 (-4.98, 18.3) 0.26 8.02 (-5.12, 23.4) 0.24
MBP 6.55 (-3.60, 16.7) 0.20 5.22 (-5.18, 15.7) 0.32 8.19 (-3.61, 21.0) 0.18
MiBP 2.42 (-5.96, 10.8) 0.57 3.46 (-4.89, 11.8) 0.41 2.86 (-6.81, 13.8) 0.58
MEP 1.36 (-9.57, 12.3) 0.81 1.00 (-10.4, 12.4) 0.86 -9.43 (-20.1, 2.51) 0.11
MCPP -0.48 (-9.45, 8.48) 0.91 4.76 (-3.69, 13.2) 0.26 -3.81 (-11.8, 6.87) 0.47
MCOP -2.17 (-12.4, 8.09) 0.67 3.93 (-5.77, 13.6) 0.42 -5.15 (-15.7, 7.06) 0.39
MCNP -2.64 (-11.7, 6.45) 0.57 2.70 (-6.31, 11.7) 0.55 -3.99 (-13.9, 6.75) 0.45
ΣDEHP 2.87 (-6.17, 11.9) 0.53 1.14 (-8.61, 10.9) 0.82 5.85 (-4.81, 17.6) 0.29
  1. CI, confidence interval, SHBG, sex hormone-binding globulin. Linear regression models adjusted for age at enrollment, prepregnancy body mass index, and urinary specific gravity.
  2. *P < 0.05.
  3. †P < 0.10.