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Table 5 Cross-sectional analysis: percent change (95% CIs) in thyroid hormone concentrations in relation to interquartile range increase in urinary phthalate metabolite concentration by visit during gestation

From: Urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels during pregnancy: a longitudinal analysis

Visit 1 (16–20 weeks)
Analyte % Change (95% CI) p-value % Change (95% CI) p-value % Change (95% CI) p-value
  Free T3 (n = 100 observations) Free T4 (n = 100 observations) ln-TSH (n = 100 observations)
MBzP 1.87 (-2.55, 6.37) 0.40 2.44 (-2.77, 7.65) 0.36 12.9 (-0.93, 28.2) 0.07†
MBP -0.72 (-4.94, 3.29) 0.73 0.26 (-4.58, 5.04) 0.92 1.29 (-10.2, 13.7) 0.83
MiBP -1.64 (-5.55, 2.42) 0.43 4.95 (0.27, 9.28) 0.04* 1.09 (-10.3, 13.9) 0.86
MEP -0.20 (-5.37, 5.02) 0.94 -0.05 (-6.10, 6.10) 0.99 0.77 (-13.6, 17.7) 0.92
MCPP -1.04 (-4.54, 2.62) 0.57 1.41 (-2.83, 5.80) 0.50 -2.57 (-12.7, 8.69) 0.64
MCOP -0.50 (-4.11, 2.93) 0.78 -0.44 (-4.58, 3.76) 0.83 -0.39 (-10.3, 10.7) 0.94
MCNP 1.05 (-2.27, 4.49) 0.53 0.43 (-3.47, 4.37) 0.83 -2.68 (-11.9, 7.35) 0.58
ΣDEHP -1.62 (-6.05, 2.85) 0.47 3.09 (-2.17, 8.27) 0.25 7.14 (-6.12, 22.3) 0.30
Visit 3 (24–28 weeks)
  Free T3 (n = 81 observations) Free T4 (n = 81 observations) ln-TSH (n = 81 observations)
MBzP -2.67 (-8.3, 2.86) 0.34 -2.97 (-12.1, 6.07) 0.51 -4.62 (-20.4, 13.5) 0.58
MBP -0.57 (-5.68, 4.34) 0.82 -1.46 (-9.67, 6.74) 0.72 9.57 (-6.27, 27.3) 0.25
MiBP -2.51 (-6.81, 1.70) 0.24 -4.70 (-11.8, 2.08) 0.17 2.74 (-9.94, 17.9) 0.68
MEP 2.76 (-2.68, 8.44) 0.32 4.93 (-3.81, 13.7) 0.27 18.1 (0.00, 37.8) 0.05†
MCPP -5.93 (-10.2, -1.75) 0.01* -5.11 (-12.5, 2.22) 0.17 2.41 (-11.1, 17.7) 0.74
MCOP -5.83 (-10.8, -0.58) 0.03* -3.02 (-11.5, 5.38) 0.47 -3.35 (-17.1, 13.6) 0.67
MCNP -1.44 (-5.92, 3.10) 0.54 -6.34 (-14.0, 0.99) 0.09† 5.39 (-8.50, 21.3) 0.46
ΣDEHP 0.05 (-4.49, 4.49) 0.98 -8.02 (-15.3, -0.80) 0.03* 2.79 (-10.8, 18.6) 0.70
  1. CI, confidence interval, TSH, thyroid-stimulating hormone. Linear regression models adjusted for age at enrollment, prepregnancy body mass index, and urinary specific gravity.
  2. *P < 0.05.
  3. †P < 0.10.