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Table 4 Longitudinal analysis: percent change (95% CIs) in thyroid and sex hormone concentrations in relation to interquartile range increase in urinary phthalate metabolite concentration

From: Urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels during pregnancy: a longitudinal analysis

Analyte % Change (95% CI) p-value % Change (95% CI) p-value % Change (95% CI) p-value
  Free T3 (n = 181 observations) Free T4 (n = 181 observations) ln-TSH (n = 181 observations)
MBzP 0.18 (-3.42, 3.77) 0.92 0.58 (-4.45, 5.56) 0.82 5.51 (-4.40, 16.5) 0.28
MBP 1.33 (-1.90, 4.67) 0.42 0.63 (-4.00, 5.21) 0.79 3.28 (-5.58, 12.8) 0.48
MiBP 0.19 (-2.86, 3.14) 0.90 1.14 (-3.06, 5.42) 0.59 4.64 (-3.73, 13.0) 0.28
MEP 1.11 (-2.74, 4.96) 0.57 2.68 (-2.68, 7.83) 0.33 0.05 (-10.1, 11.3) 0.99
MCPP -2.89 (-5.65, -0.02) 0.049* -2.01 (-6.12, 2.10) 0.34 1.60 (-6.05, 9.88) 0.68
MCOP -2.03 (-5.08, 0.98) 0.18 -1.11 (-5.26, 3.13) 0.61 -2.52 (-10.3, 6.13) 0.56
MCNP 0.48 (-2.03, 2.94) 0.71 -1.64 (-5.28, 1.93) 0.36 3.50 (-2.98, 10.4) 0.30
ΣDEHP -0.28 (-3.63, 0.30) 0.87 -0.93 (-5.56, 3.79) 0.70 7.21 (-1.87, 16.6) 0.12
  Estradiol (n = 175 observations) SHBG (n = 147 observations) ln-progesterone (n = 179 observations)
MBzP 0.86 (-8.52, 10.3) 0.86 4.89 (-1.52, 11.3) 0.13 3.16 (-4.56, 11.5) 0.67
MBP 2.65 (-5.90, 11.2) 0.54 -0.65 (-6.29, 4.98) 0.82 3.71 (-3.44, 11.2) 0.31
MiBP 1.56 (-6.27, 9.39) 0.69 1.19 (-4.25, 6.61) 0.66 2.48 (-3.96, 9.49) 0.46
MEP 1.60 (-8.49, 11.7) 0.75 -2.24 (-9.43, 4.97) 0.54 -10.6 (-17.6, -2.84) 0.01*
MCPP -3.86 (-11.5, 3.80) 0.32 -1.27 (-6.40, 3.86) 0.62 -4.31 (-10.2, 1.98) 0.17
MCOP -3.59 (-11.4, 4.24) 0.36 -0.93 (-6.44, 4.58) 0.74 -4.83 (-11.0, 1.57) 0.13
MCNP -2.03 (-8.50, 4.41) 0.53 -0.66 (-4.85, 3.46) 0.75 -2.06 (-7.22, 3.28) 0.43
ΣDEHP -0.56 (-9.17, 8.06) 0.90 -4.11 (-9.83, 1.62) 0.16 1.79 (-5.17, 9.39) 0.62
  1. CI, confidence interval, TSH, thyroid-stimulating hormone, SHBG, sex hormone-binding globulin. Linear mixed models include a random intercept for subject ID and are adjusted for age at enrollment, prepregnancy body mass index, as well as urinary specific gravity and study visit.
  2. *P < 0.05.