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Table 2 Change (∆) in hormone parameters from study day 1 to day 4, following 2 days of Metformin or placebo treatment

From: Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects

Static parameters Metformin p Placebo p p
   Within group   Within group Between group
T (ug/l) −0.071 ± 0.147 0.16 0.109 ± 0.306 0.32 0.13
SHBG (nmol/l) −1.430 ± 7.456 0.56 −3.056 ± 5.787 0.15 0.61
FAI −0.640 ± 2,187 0.93 2.311 ± 3.742 0.10 0.05
DHEAS (mg/l) 0.153 ± 0.385 0.24 −0.004 ± 0.240 0.96 0.31
A (μg/l) 0.00 ± 0.158 0.35 −0.278 ± 0.151 0.97 0.22
17-OHP (μg/l) 0.490 ± 0.872 0.59 −0.106 ± 0.114 0.38 0.30
Free T (pg/ml) 0.00 ± 0.158 1.0 −0.278 ± 0.151 0.10 0.22
E2 (ng/l) 4.899 ± 4.942 0.35 −2.429 ± 4.117 0.58 0.27
Dynamic parameters      
AUC Testosterone −8.100 ± 2.188 0.005 4.524 ± 4.69 0.36 0.02
AUC SHBG −112.725 ± 143.358 0.45 −320.333 ± 119.331 0.028 0.11
AUC DHEAS 10,501 ± 26,467 0.24 1,508 ± 21,924 0.84 0.45
AUC A −25.275 ± 13.524 0.09 −3.083 ± 16.652 0.86 0.45
AUC 17-OHP 1.568 ± 4.698 0.75 −8.449 ± 6.412 0.22 0.40
AUC Free T −26.325 ± 8.058 0.01 −18.167 ± 9.014 0.08 0.45
AUC E2 273.214 ± 374.027 0.49 −247.500 ± 288.740 0.42 0.46
  1. Statistically significant differences are shown in boldface.