| |
Metformin
|
Placebo
|
|---|
|
No. of subjects
|
10
|
9
|
|
Age (yrs)
|
26.10 ± 4.25
|
27.89 ± 4.83
|
|
Weight (kg)
|
78.97 ± 21,86
|
95.26 ± 21.64
|
|
BMI (kg/m2)
|
29.90 ± 7.41
|
32.15 ± 6.10
|
|
No. with oligomenorrhea (%)
|
10 (100%)
|
8 (89%)
|
|
No. with PCO on ultrasound (%)
|
8 (80%)
|
7 (78%)
|
|
Total testosterone (μg/l)
|
0.58 ± 0.24
|
0.66 ± 0.36
|
|
SHBG (nmol/l)
|
35.60 ± 24.09
|
39.02 ± 33.30
|
|
Free testosterone (pg/ml)
|
1.77 ± 0.99
|
1.92 ± 0.91
|
|
Androstendione (μg/l)
|
3.65 ± 1.47
|
3.61 ± 0.91
|
|
17-OHP (μg/l)
|
1.35 ± 0.37
|
1.22 ± 0.49
|
|
Free androgen Index
|
7.78 ± 4.96
|
7.92 ± 3.26
|
|
Estradiol (ng/l)
|
36.56 ± 14.06
|
48.00 ± 20.77
|
|
DHEAS (mg/l)
|
2.50 ± 0.97
|
1.84 ± 0.79
|
|
Fasting glucose (mg/dl)
|
81.80 ± 6.03
|
86.89 ± 6.57
|
|
AUC glucose
|
18409.70 ± 2059.30
|
17987.67 ± 2264.72
|
|
(mg/dl x 180 min)
|
|
Fasting insulin (μIU/ml)
|
11.06 ± 6.38
|
18.04 ± 10.66
|
|
AUC insulin
|
12754.40 ± 8060.54
|
16671 ± 12663.37
|
|
(μUI/ml x 180 min)
|
|
No. with IR* (%)
|
3 (30%)
|
5 (56%)
|
- Data are given as mean ± SEM unless otherwise noted.
- *IR was defined as AUC insulin > 12,000 μUI/ml x 180 min.
