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Table 3 EC 50 of 17β estradiol (E 2 ); the phyotoestogen, genistein; the sesquiterpenoid, ferutinin; the traditional Chinese medicine (TCM); and the six selected components of the herbal medicine that were determined in the HELN-ERα, HELN-ERβ, HELN-ΔA/BERα, and HELN-ΔA/BERβ cell lines

From: Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine

  ERα ΔΑ/β ERα ERβ ΔΑ/β ERβ ERα vs ERβ
p-value
  EC 50 (nM)  
E 2 0.017 0.034 0.068 0.22  
Genistein 18.8 49.4 6.1 18.8  
Ferutinin 0.64 0.65 3.9   
  EC 50 (%)  
Traditional Chinese medicine 0.035 0.055 0.015 0.035 0.015
B 0.2 0.25 0.055 0.15 0.003
F 0.2 0.2 0.03 0.1 <0.001
J 0.04 0.04 0.02 0.03 NS
L 0.3 0.3 0.4 0.4 NS
P 0.004 0.007 0.002 0.004 NS
R 0.07 0.08 0.035 0.06 NS
  1. The EC50 values for E2, genistein, and ferutinin are expressed in nM, whereas those of the TCM and the components are expressed as percentages and correspond to dilutions of the TCM or components (1% = 100-fold dilution). Significant p-values corresponding to Student's t-test are reported (NS: not significant at the 5% significance level).
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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