|
Secreted by
|
Pituitary
|
Embryo and placenta
|
|
Physiological role
|
Support follicle development (14 days)
|
Support implantation and pregnancy (282 days)
|
|
Binding affinity
|
Lower
|
Higher (2x)
|
|
Half-life
|
Shorter (23 h sc)
|
Longer (32–33 h sc)
|
|
Accumulation
|
Slight
|
Significant and down regulation of LH receptor
|
|
Stimulation of LH receptor
|
Physiological
|
Pharmacological, leading to LH receptor down regulation
|
|
Equivalency
|
6–8 IU of LH
|
1 IU of hCG
|
|
Purity
|
99%
|
99% purity for r-hCG and 70% in HP-hMG (39 identified contaminants)
|
|
Sources
|
r-hLH
|
r-hCG, urinary hCG or hMG
|
|
Induction of steroid (testosterone, oestradiol and progesterone) production
|
Higher LH = higher steroid production
|
Higher hCG = higher steroid production
|
|
Filling system
|
Filled by mass
|
Filled by Mass for r-hCG and Filled by IU for hCG/hMG
|
|
Gene activation
|
Differential unexplained
|
Differential unexplained
|
|
Cytokine production
|
Differential unexplained
|
Differential unexplained
|
|
Embryo quality production
|
Not objectively proven
|
Not objectively proven
|
