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Table 6 Genes previously described to be progesterone regulated that are up-regulated in endometrium of subjects with repeated embryo implantation failure

From: Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation

UniGene ID Gene symbol Gene title Down regulated in window of implantation Up regulated in endometriosis or RU486 Fold change p value
Hs.208854 CD69 CD69 antigen (p60, early T-cell activation antigen)   [7] 2,3 0.00022
Hs.406515 NQO1 NAD(P)H dehydrogenase, quinone 1 [29]   2,2 0.00043
Hs.335614 SEC14L2 SEC14-like 2 (S. cerevisiae), mRNA.   [4] 1,9 0.00013
Hs.481181 NEK1 NIMA (never in mitosis gene a)-related kinase 1 (NEK1), mRNA. [29]   1,6 0.00043
Hs.86368 CLGN Calmegin, mRNA.   [7] 1,5 0.00086
Hs.189075 TWF1 Twinfilin, actin-binding protein, homolog 1 (Drosophila)   [4] 1,5 0.00043
Hs.127680 LOC389332 PREDICTED: hypothetical LOC389332 (LOC389332), mRNA.   [4] 1,4 0.00013
Hs.369430 PAM Peptidylglycine alpha-amidating monooxygenase, transcript variant 3, mRNA. [24, 28]   1,1 0.00022
Hs.514806 GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1), mRNA.   [7] 1,1 0.00043
Hs.509447 GRLF1 Glucocorticoid receptor DNA binding factor 1   [7] 1,1 0.00086
Hs.481927 NIPBL Nipped-B homolog (Drosophila)   [7] 1,1 0.00086
Hs.444558 KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3, mRNA. [24, 29, 32] [4] 1,1 0.00043
Hs.495710 GPM6B Glycoprotein M6B (GPM6B), transcript variant 4, mRNA. [29]   1,0 0.00022
Hs.496414 ATP7A ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) [29]   1,0 0.00043
  1. Data is expressed as fold change for endometrial genes up-regulated ≥2-fold in group A vs. group B that have been shown either down-regulated during the window of implantation or up-regulated in women with endometriosis or treated with mifepristone. Bolded transcripts are increased also in group A vs. Group C.