Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation

Table 6 Genes previously described to be progesterone regulated that are up-regulated in endometrium of subjects with repeated embryo implantation failure

UniGene ID	Gene symbol	Gene title	Down regulated in window of implantation	Up regulated in endometriosis or RU486	Fold change	p value
Hs.208854	CD69	CD69 antigen (p60, early T-cell activation antigen)		[7]	2,3	0.00022
Hs.406515	NQO1	NAD(P)H dehydrogenase, quinone 1	[29]		2,2	0.00043
Hs.335614	SEC14L2	SEC14-like 2 (S. cerevisiae), mRNA.		[4]	1,9	0.00013
Hs.481181	NEK1	NIMA (never in mitosis gene a)-related kinase 1 (NEK1), mRNA.	[29]		1,6	0.00043
Hs.86368	CLGN	Calmegin, mRNA.		[7]	1,5	0.00086
Hs.189075	TWF1	Twinfilin, actin-binding protein, homolog 1 (Drosophila)		[4]	1,5	0.00043
Hs.127680	LOC389332	PREDICTED: hypothetical LOC389332 (LOC389332), mRNA.		[4]	1,4	0.00013
Hs.369430	PAM	Peptidylglycine alpha-amidating monooxygenase, transcript variant 3, mRNA.	[24, 28]		1,1	0.00022
Hs.514806	GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1), mRNA.		[7]	1,1	0.00043
Hs.509447	GRLF1	Glucocorticoid receptor DNA binding factor 1		[7]	1,1	0.00086
Hs.481927	NIPBL	Nipped-B homolog (Drosophila)		[7]	1,1	0.00086
Hs.444558	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3, mRNA.	[24, 29, 32]	[4]	1,1	0.00043
Hs.495710	GPM6B	Glycoprotein M6B (GPM6B), transcript variant 4, mRNA.	[29]		1,0	0.00022
Hs.496414	ATP7A	ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)	[29]		1,0	0.00043

Data is expressed as fold change for endometrial genes up-regulated ≥2-fold in group A vs. group B that have been shown either down-regulated during the window of implantation or up-regulated in women with endometriosis or treated with mifepristone. Bolded transcripts are increased also in group A vs. Group C.

ISSN: 1477-7827