Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis

Table 4 Stratification analyses of genetic susceptibility of rs1256049 polymorphism to male infertility

Category	Cases/Controls	AA vs. GG			GA vs. GG			AA + GA vs. GG			AA vs. GA + GG			A allele vs. G allele
		OR(95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²
Total	1378/1478	0.57(0.32-1.01)	0.940	0	1.59(1.12-2.25) ^b	0.047	50.9	1.30(1.05-1.61)	0.075	45.7	0.55(0.32-0.96)	0.920	0	1.29(0.97-1.72)	0.068	46.9
*RACE*
Asian	1056/991	0.57(0.32-1.01)	0.853	0	1.52(1.00-2.31) ^b	0.038	60.6	1.23(0.98-1.56)	0.064	55	0.55(0.31-0.97)	0.818	0	1.19(0.86-1.65)	0.067	54.4
Caucasian	322/487	0.64(0.03-15.86)	-	-	1.87(0.92-3.80)	0.208	36.2	1.74(1.03-2.94)	0.275	22.6	0.58(0.02-14.38)	-	-	1.66(0.99-2.77)	0.372	0

^aP value of Q-test for heterogeneity test.
^bRandom-effects model was used when a P value, 0.05 for heterogeneity test; otherwise, fixed-effects model was used.
I²: 0–25, no heterogeneity; 25–50, modest heterogeneity; 50, high heterogeneity.
Bold numbers mean statistically significant results.

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