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Table 4 Stratification analyses of genetic susceptibility of rs1256049 polymorphism to male infertility

From: Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis

Category Cases/Controls AA vs. GG GA vs. GG AA + GA vs. GG AA vs. GA + GG A allele vs. G allele
   OR(95% CI) P a I 2 OR(95% CI) P a I 2 OR(95% CI) P a I 2 OR(95% CI) P a I 2 OR(95% CI) P a I 2
Total 1378/1478 0.57(0.32-1.01) 0.940 0 1.59(1.12-2.25) b 0.047 50.9 1.30(1.05-1.61) 0.075 45.7 0.55(0.32-0.96) 0.920 0 1.29(0.97-1.72) 0.068 46.9
RACE                 
Asian 1056/991 0.57(0.32-1.01) 0.853 0 1.52(1.00-2.31) b 0.038 60.6 1.23(0.98-1.56) 0.064 55 0.55(0.31-0.97) 0.818 0 1.19(0.86-1.65) 0.067 54.4
Caucasian 322/487 0.64(0.03-15.86) - - 1.87(0.92-3.80) 0.208 36.2 1.74(1.03-2.94) 0.275 22.6 0.58(0.02-14.38) - - 1.66(0.99-2.77) 0.372 0
  1. aP value of Q-test for heterogeneity test.
  2. bRandom-effects model was used when a P value, 0.05 for heterogeneity test; otherwise, fixed-effects model was used.
  3. I2: 0–25, no heterogeneity; 25–50, modest heterogeneity; 50, high heterogeneity.
  4. Bold numbers mean statistically significant results.