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Figure 3 | Reproductive Biology and Endocrinology

Figure 3

From: Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy

Figure 3

The percentage of Th17 and Treg cells in peripheral blood mononuclear cells and the Th17/Treg ratio varies in patients with a successful pregnancy after immunotherapy. The percentage of Th17 and Treg cells in peripheral blood mononuclear cells were detected by flow cytometry in patients with successful pregnancy after immunotherapy. To date, 13 of the 20 patients have become newly pregnant. Of the 13, the 11 patients did not miscarry (successful group). (a) The percentage of Th17 cells in peripheral blood mononuclear cells significantly decreased after immunotherapy. The percentage of Treg cells in peripheral blood mononuclear cells significantly increased after immunotherapy (P < 0.01, paired t-test). Bar represents the CD4+/IL-17A + cell frequency and the means ± S.E. are indicated (b) The Th17/Treg ratio in peripheral blood mononuclear cells significantly decreased after immunotherapy (P < 0.01, paired t-test). Bar represent the frequency of CD4+/CD25bright/Foxp3+ cells and the means ± S.E. are indicated. Representative CD4+/IL-17A + flow cytometry plots from patients with successful pregnancies were shown before (c) and after (d) immunotherapy. Representative CD4+/CD25bright Foxp3+ flow cytometry plots from patients with successful pregnancies were shown before (e) and after (f) immunotherapy.

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