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Table 1 Body weight, plasma parameters and organ weights in offspring

From: Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life

 

CON male (n)

DIO male (n)

p value

CON female (n)

DIO female (n)

p value

n = 22 from 9 litters

n = 16 from 10 litters

 

n = 18 from 9 litters

n = 19 from 10 litters

Birthwt (g) (litter mean)

1.37 +/- 0.04

1.30 +/- 0.11

0.54

1.30 +/- 0.06

1.21 +/- 0.07

0.39

Wean wt (g) (litter mean)

8.42 +/- 0.53

10.54 +/- 0.28

0.002

7.91 +/- 0.20

9.70 +/- 0.20

<0.001

Post-wean group

CON/CON

CON/DIO

DIO/CON

DIO/DIO

p value

CON/CON

CON/DIO

DIO/CON

DIO/DIO

p value

male n = 8

male n = 8

male n = 8

male n = 8

 

female n = 8

female n = 8

female n = 8

female n = 7

3 months

Plasma cholesterol mmol/l

2.47 +/- 0.34

5.28 +/- 0.57

2.73 +/- 0.20

7.01 +/- 0.39

a:p < 0.001

3.16 +/- 0.50

4.67 +/- 0.53

2.47 +/- 0.23

3.89 +/- 0.34

a:p = 0.003

b:p = ns

b:p = 0.016

Plasma TG mmol/l

0.57 +/- 0.06

0.66 +/- 0.10

0.53 +/- 0.11

0.63 +/- 0.83

a:p = ns

0.61 +/- 0.06

0.72 +/- 0.08

0.56 +/- 0.07

0.52 +/- 0.11

a:p = ns

b:p = ns

b:p = ns

Plasma glucose AUC

985 +/- 55

1668 +/- 203

1056 +/- 108

2037+/- 139

a:p < 0.001

898 +/- 109

1087 +/- 123

1026 +/- 121

1197 +/- 97

a:p = ns

b:p = ns

b:p = ns

Plasma insulin AUC

74 +/- 6

247 +/- 22

77 +/- 11

177 +/- 16

a:p < 0.001

60 +/- 5

110 +/- 13

57 +/- 3

90 +/- 12

a:p < 0.001

b:p = ns

b:p = 0.03

HOMA IR

1.55 +/- 0.12

5.43 +/- 0.57

1.61 +/- 0.24

4.19 +/- 0.58

a:p < 0.001

1.27 +/- 0.07

2.43 +/- 0.33

1.16 +/- 0.06

1.65 +/- 0.22

a:p00.01

b:p = 0.044

b:p = ns

6 months

Plasma cholesterol mmol/l

2.87 +/- 0.39

9.37 +/- 0.46

4.06 +/- 0.29

7.77 +/- 0.51

a:p < 0.001

3.92 +/- 0.38

6.65 +/- 0.55

2.98 +/- 0.41

6.26 +/- 0.26

a:p < 0.001

b:p = ns

b:p = ns

Plasma TG mmol/l

0.55 +/- 0.09

0.71 +/- 0.05

0.63 +/- 0.06

0.71 +/- 0.07

a:p = ns

0.63 +/- 0.08

0.83 +/- 0.03

0.51 +/- 0.10

0.66 +/- 0.09

a:p = 0.045

b:p = ns

b:p = ns

Plasma glucose AUC

1189 +/- 125

2287 +/- 280

1205 +/- 163

2074 +/- 143

a:p < 0.001

1005 +/- 92

1420 +/- 163

886 +/- 1487

1487 +/- 162

a:p < 0.001

b:p = ns

b:p = ns

Plasma insulin AUC

109 +/- 17

581 +/- 61

129 +/- 14

535+/-52

a:p < 0.001

78 +/- 13

169 +/- 29

66 +/- 6

173 +/- 16

a:p < 0.001

b:p = ns

b:p = ns

HOMA-IR

2.24 +/- 0.34

11.56 +/- 1.17

2.77 +/- 0.32

10.47 +/- 0.92

a:p < 0.001

1.57 +/- 0.31

3.41 +/- 0.58

1.38 +/- 0.13

3.72 +/- 0.38

a:p < 0.001

b:p = ns

b:p = ns

Liver

4.11 +/- 0.10

3.70 +/- 0.52

3.98 +/- 0.10

4.24 +/- 0.38

a:p = ns

4.02 +/- 0.19

3.68 +/- 0.10

4.04 +/- 0.09

3.63 +/- 0.16

a:p = 0.014

b:p = ns

b:p = ns

RP fat pad

0.29 +/- 0.08

0.97 +/- 0.07

0.30 +/- 0.02

0.94 +/- 0.10

a:p < 0.001

0.28 +/- 0.05

0.97 +/- 0.18

0.31 +/- 0.07

1.56 +/- 0.16

a:p < 0.001

b:p = 0.023

b:p = ns

Mes fat pad

0.42 +/- 0.09

1.39 +/- 0.14

0.74 +/- 0.07

1.40 +/- 0.24

a:p < 0.001

0.37 +/- 0.06

0.76 +/- 0.10

0.45 +/- 0.10

1.02 +/- 0.10

a:p < 0.001

b:p = ns

b:p = ns

SC fat pad

0.96 +/- 0.11

2.92 +/- 0.20

0.92 +/- 0.06

2.74 +/- 0.24

a:p < 0.001

0.75 +/- 0.09

2.44 +/- 0.23

0.80 +/- 0.12

2.44 +/- 0.11

a:p < 0.001

b:p = ns

b:p = ns

Epi fat pad

0.90 +/- 0.13

2.26 +/- 0.14

0.87 +/- 0.14

2.28 +/- 0.15

a:p < 0.001

     

b:p = ns

  1. Organ weights expressed as a% of body weight (TG = triglycerides, RP = retroperitoneal fat, Mes = mesenteric fat, SC = subcutaneous fat, Epi = epididymal fat). a = effect of postnatal diet, b = effect of maternal obesity for all groups compared to CON/CON.