Skip to main content

Table 1 Body weight, plasma parameters and organ weights in offspring

From: Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life

  CON male (n) DIO male (n) p value CON female (n) DIO female (n) p value
n = 22 from 9 litters n = 16 from 10 litters   n = 18 from 9 litters n = 19 from 10 litters
Birthwt (g) (litter mean) 1.37 +/- 0.04 1.30 +/- 0.11 0.54 1.30 +/- 0.06 1.21 +/- 0.07 0.39
Wean wt (g) (litter mean) 8.42 +/- 0.53 10.54 +/- 0.28 0.002 7.91 +/- 0.20 9.70 +/- 0.20 <0.001
Post-wean group CON/CON CON/DIO DIO/CON DIO/DIO p value CON/CON CON/DIO DIO/CON DIO/DIO p value
male n = 8 male n = 8 male n = 8 male n = 8   female n = 8 female n = 8 female n = 8 female n = 7
3 months
Plasma cholesterol mmol/l 2.47 +/- 0.34 5.28 +/- 0.57 2.73 +/- 0.20 7.01 +/- 0.39 a:p < 0.001 3.16 +/- 0.50 4.67 +/- 0.53 2.47 +/- 0.23 3.89 +/- 0.34 a:p = 0.003
b:p = ns
b:p = 0.016
Plasma TG mmol/l 0.57 +/- 0.06 0.66 +/- 0.10 0.53 +/- 0.11 0.63 +/- 0.83 a:p = ns 0.61 +/- 0.06 0.72 +/- 0.08 0.56 +/- 0.07 0.52 +/- 0.11 a:p = ns
b:p = ns
b:p = ns
Plasma glucose AUC 985 +/- 55 1668 +/- 203 1056 +/- 108 2037+/- 139 a:p < 0.001 898 +/- 109 1087 +/- 123 1026 +/- 121 1197 +/- 97 a:p = ns
b:p = ns
b:p = ns
Plasma insulin AUC 74 +/- 6 247 +/- 22 77 +/- 11 177 +/- 16 a:p < 0.001 60 +/- 5 110 +/- 13 57 +/- 3 90 +/- 12 a:p < 0.001
b:p = ns
b:p = 0.03
HOMA IR 1.55 +/- 0.12 5.43 +/- 0.57 1.61 +/- 0.24 4.19 +/- 0.58 a:p < 0.001 1.27 +/- 0.07 2.43 +/- 0.33 1.16 +/- 0.06 1.65 +/- 0.22 a:p00.01
b:p = 0.044
b:p = ns
6 months
Plasma cholesterol mmol/l 2.87 +/- 0.39 9.37 +/- 0.46 4.06 +/- 0.29 7.77 +/- 0.51 a:p < 0.001 3.92 +/- 0.38 6.65 +/- 0.55 2.98 +/- 0.41 6.26 +/- 0.26 a:p < 0.001
b:p = ns
b:p = ns
Plasma TG mmol/l 0.55 +/- 0.09 0.71 +/- 0.05 0.63 +/- 0.06 0.71 +/- 0.07 a:p = ns 0.63 +/- 0.08 0.83 +/- 0.03 0.51 +/- 0.10 0.66 +/- 0.09 a:p = 0.045
b:p = ns
b:p = ns
Plasma glucose AUC 1189 +/- 125 2287 +/- 280 1205 +/- 163 2074 +/- 143 a:p < 0.001 1005 +/- 92 1420 +/- 163 886 +/- 1487 1487 +/- 162 a:p < 0.001
b:p = ns
b:p = ns
Plasma insulin AUC 109 +/- 17 581 +/- 61 129 +/- 14 535+/-52 a:p < 0.001 78 +/- 13 169 +/- 29 66 +/- 6 173 +/- 16 a:p < 0.001
b:p = ns
b:p = ns
HOMA-IR 2.24 +/- 0.34 11.56 +/- 1.17 2.77 +/- 0.32 10.47 +/- 0.92 a:p < 0.001 1.57 +/- 0.31 3.41 +/- 0.58 1.38 +/- 0.13 3.72 +/- 0.38 a:p < 0.001
b:p = ns
b:p = ns
Liver 4.11 +/- 0.10 3.70 +/- 0.52 3.98 +/- 0.10 4.24 +/- 0.38 a:p = ns 4.02 +/- 0.19 3.68 +/- 0.10 4.04 +/- 0.09 3.63 +/- 0.16 a:p = 0.014
b:p = ns
b:p = ns
RP fat pad 0.29 +/- 0.08 0.97 +/- 0.07 0.30 +/- 0.02 0.94 +/- 0.10 a:p < 0.001 0.28 +/- 0.05 0.97 +/- 0.18 0.31 +/- 0.07 1.56 +/- 0.16 a:p < 0.001
b:p = 0.023
b:p = ns
Mes fat pad 0.42 +/- 0.09 1.39 +/- 0.14 0.74 +/- 0.07 1.40 +/- 0.24 a:p < 0.001 0.37 +/- 0.06 0.76 +/- 0.10 0.45 +/- 0.10 1.02 +/- 0.10 a:p < 0.001
b:p = ns
b:p = ns
SC fat pad 0.96 +/- 0.11 2.92 +/- 0.20 0.92 +/- 0.06 2.74 +/- 0.24 a:p < 0.001 0.75 +/- 0.09 2.44 +/- 0.23 0.80 +/- 0.12 2.44 +/- 0.11 a:p < 0.001
b:p = ns
b:p = ns
Epi fat pad 0.90 +/- 0.13 2.26 +/- 0.14 0.87 +/- 0.14 2.28 +/- 0.15 a:p < 0.001      
b:p = ns
  1. Organ weights expressed as a% of body weight (TG = triglycerides, RP = retroperitoneal fat, Mes = mesenteric fat, SC = subcutaneous fat, Epi = epididymal fat). a = effect of postnatal diet, b = effect of maternal obesity for all groups compared to CON/CON.