Effect of hormones on total and bone specific alkaline phosphatase (ALP). a) There was no significant change in the level of total ALP was observed at 10 months time point. b) Bone specific ALP levels were increased significantly in combination of hormone treatments. AI treatment reduced the bone specific ALP levels in the serum showing reduced bone formation process. Since, all 5, 10 and 15-month time points showed similar trend, 10-month time point was taken as a representative result. All values are expressed as Mean ± SD and p ≤ 0.05 was considered statistically significant. *- represents significant difference between AI treatment and other hormone treatments, #- represents significant difference between ovariectomized control and AI treatment.