Table 1 Comparison of general parameters from P1, P2 and P3
From: Bilateral uterine vessel ligation as a model of intrauterine growth restriction in mice
Parameters | P1 | P2 | P3 | ||||
|---|---|---|---|---|---|---|---|
Ctrl | Test | Ctrl | Test | Ctrl | Test | ||
Pregnancy outcomes | Weight monitoring | + 9 | −21 | −6 | −18 | −1 | −22 |
± 1% | ± 5% | ± 1% | ±8% | +/−3% | +/−10% | ||
Abortion | 0% | 100% | 0% | 43% | 0% | 75% | |
Mean number of fetuses | |||||||
at surgery (D0*) | 8 +/− 1 | 7 +/− 1 | 7 +/− 1 | 7 +/− 1 | 8 +/− 0 | 9 + −/ 1 | |
at extraction (E18.5) | 8 +/− 1 | 4 +/− 2 | 7 +/− 1 | 6 +/− 2 | 8 +/− 0 | 4 +/− 2 | |
Fetal data | Fetal resorption | 0 | 25 | 0 | 0 | 0 | 37 |
(E18.5) | +/− 0% | +/−30% | +/−0% | +/−0% | +/−0% | +/−33% | |
Fetal viabiliy | 92 | 8 | 90 | 59. | 100 | 27 | |
+/−6% | +/−14% | +/−7% | +/−22% | +/−0% | +/−33% | ||
Mean weight of fetuses | 0.92 | 0.45 | 0.98 | 0.89 | 1.05 | 0.54 | |
± 0.10 g | ± 0.24 g | ± 0.05 g | ±0.08 g | ± 0.04 g | ± 0.21 g | ||
IUGR? | - | Yes | - | No | - | Yes | |
Fetuses with IUGR | 13% | 73% | 20% | 37% | 4% | 61% | |
Mean fetal weight: Placental weight ratio | 9.0 +/− 1.0 | 4.7+/−2.3 | 9.5+/1.6 | 10.2+/−1.9 | 9.8+/−0.2 | 7.0+/−1.9 | |
Mean size of the fetuses | 1.38 | 0.92 | 1.31 | 1.25 | 1.8 | 1.08 | |
±0.29 cm2 | ± 0.42 cm2 | ±0.20 cm2 | ±0.25 cm2 | ±0.14 cm2 | ±0.35 cm2 | ||
Mean weight of placentas | 0.10 | 0.08 | 0.11 | 0.08 | 0.11 | 0.07 | |
± 0.02 g | ± 0.02 g | ± 0.02 g | ± 0.03 g | ± 0.01 g | ± 0.01 g | ||