Figure 5
From: Molecular aspects of development and regulation of endometriosis
STAT1 as an integral factor of IGF, HGF, EGF, IL-6, and PDGF signaling pathways. STAT1, 3, and 5 are primarily activated by growth factors and regulate proliferation and apoptosis. A number of growth factors are known to contribute to the increased proliferative potential of cells derived from endometriotic lesions. The effects of such factors as EGF, PDGF, FGFR, IL-6, HGF and VEGF are all primarily achieved through STAT activation.